公开(公告)号：US20120083533A1

公开(公告)日：2012-04-05

申请号：US13251871

申请日：2011-10-03

申请人： Francesco Della Valle ,  Raffacle Migliaccio ,  Maria Federica Della Valle

发明人： Francesco Della Valle ,  Raffacle Migliaccio ,  Maria Federica Della Valle

IPC分类号： A61K31/164 ,  A61P19/04 ,  A61P13/12 ,  C07C235/08 ,  C07C233/20

CPC分类号： A61K31/164 ,  A61K31/198

摘要： A therapy for renal diseases, in particular renal diseases which develop in diabetic patients or patients who have been subjected to a treatment with an antitumor chemotherapy such as a platinum derivative and more generally cytotoxic drugs at renal level for treating of neoplastic diseases. More particularly, the present invention relates to palmitoylethanolamide and diethanolamide of fumaric acid for use in the treatment of renal diseases, in particular those caused by dysmetabolic diseases or by toxic or chemotherapy agents, such as platinum derivatives. Palmitoylethanolamide is used preferably in micronized or ultra-micronized form. Diethanolamide of fumaric acid is used preferably in aqueous solution.

摘要翻译： 一种治疗肾脏疾病，特别是在糖尿病患者中发展的肾脏疾病或已经用抗肿瘤化学疗法例如铂衍生物治疗的患者，以及更常见的用于肾脏水平的细胞毒性药物治疗肿瘤性疾病的患者。 更具体地说，本发明涉及富马酸的棕榈酰乙醇酰胺和二乙醇酰胺，用于治疗肾脏疾病，特别是由代谢异常疾病引起的或通过有毒或化学药剂如铂衍生物。 棕榈酰乙醇酰胺优选以微粉化或超微粉化形式使用。 富马酸的二乙醇酰胺优选在水溶液中使用。