公开(公告)号：US11667621B2

公开(公告)日：2023-06-06

申请号：US17251771

申请日：2019-06-11

申请人： STEVENS INSTITUTE OF TECHNOLOGY ,  MEMORIAL SLOAN-KETTERING CANCER CENTER ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Abhishek Sharma ,  Sarat Chandarlapaty ,  Lucia Wang ,  Shengjia Lin ,  Weiyi Toy ,  John Katzenellenbogen

IPC分类号： C07D401/04 ,  C07C233/20 ,  C07C233/21 ,  C07D209/12 ,  C07D333/64 ,  C07D409/14

CPC分类号： C07D401/04 ,  C07C233/20 ,  C07C233/21 ,  C07D209/12 ,  C07D333/64 ,  C07D409/14

摘要： A genus of proteolysis-targeting chimeras (PROTACs)-type compounds/antiestrogens has now been found that act as selective estrogen receptor degraders (SERDs) and estrogen receptor antagonists by degrading and antagonizing ERa in breast cancer cells. The compounds are of the following genus: The compounds described herein exhibit anti-proliferative effects, and are potentially useful, alone or in combination with other therapies, for the treatment of breast cancer. In general, these compounds combine a tight binding ERa targeting ligand tethered to a recognition motif or degron. Once bound, the degron recruits destructive cellular components and the targeted receptor (i.e., ERa) is degraded (i.e., destroyed) or antagonized.

公开(公告)号：US20220064114A1

公开(公告)日：2022-03-03

申请号：US17500593

申请日：2021-10-13

申请人： TriOptoTec GmbH

发明人： Andreas SPÄTH ,  Anja EICHNER

IPC分类号： C07D213/30 ,  C07C49/755 ,  C07C69/56 ,  C07C69/76 ,  C07C211/62 ,  C07C233/18 ,  C07C233/20 ,  C07C317/22 ,  C07D303/18 ,  C07D309/14 ,  C07F7/02 ,  C07F7/18

摘要： A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

公开(公告)号：US11174235B2

公开(公告)日：2021-11-16

申请号：US16440663

申请日：2019-06-13

申请人： ChampionX USA Inc.

发明人： Jeff Michael Servesko ,  Jeremy Wayne Bartels ,  Regan Andrew Jones ,  Corbin Metoyer

IPC分类号： C07D295/15 ,  C07C229/24 ,  C02F1/68 ,  C07C67/12 ,  C07C227/10 ,  C07C231/12 ,  C07C233/20 ,  C10G75/04 ,  C10L3/10 ,  C10L10/04

摘要： This disclosure relates to anti-agglomerant low dosage hydrate inhibitors that can inhibit the formation of hydrate agglomerants and/or plugs. Thus, provided herein are carboxy alkyl ester compounds that can be used in hydrate inhibitor compositions and methods of inhibiting formation of hydrate agglomerants in a fluid comprising water, a gas, and optionally a liquid hydrocarbon. Also provided herein are methods of making the carboxy alkyl ester compound.

公开(公告)号：US20200339504A1

公开(公告)日：2020-10-29

申请号：US16925165

申请日：2020-07-09

申请人： Ecolab USA Inc.

发明人： Anahita Khanlari ,  Andrew R. Neilson

IPC分类号： C07C233/20 ,  C07C231/02 ,  C07C15/24 ,  C10G75/04 ,  C07D211/76 ,  C07D211/94 ,  C09K15/18 ,  C07C31/20 ,  C10G9/16

摘要： Disclosed are compositions and methods for preventing or reducing polymer formation and polymer deposition in equipment used in petrochemical processes. An antifoulant composition includes a combination of one or more antioxidants; one or more antipolymerants; one or more dispersants; and one or more solvents. A method of preventing or reducing fouling of process equipment used in an industrial process is also described. The method includes introducing into the process equipment an antifoulant composition, the antifoulant composition comprising a combination of one or more antioxidants; one or more antipolymerants; one or more dispersants; and one or more solvents.

公开(公告)号：US20190382360A1

公开(公告)日：2019-12-19

申请号：US16440663

申请日：2019-06-13

申请人： Ecolab USA Inc.

发明人： Jeff Michael Servesko ,  Jeremy Wayne Bartels ,  Regan Andrew Jones ,  Corbin Metoyer

IPC分类号： C07D295/15 ,  C10L3/10 ,  C10G75/04 ,  C07C229/24 ,  C07C227/10 ,  C07C67/12 ,  C07C233/20 ,  C07C231/12 ,  C10L10/04 ,  C02F1/68

摘要： This disclosure relates to anti-agglomerant low dosage hydrate inhibitors that can inhibit the formation of hydrate agglomerants and/or plugs. Thus, provided herein are carboxy alkyl ester compounds that can be used in hydrate inhibitor compositions and methods of inhibiting formation of hydrate agglomerants in a fluid comprising water, a gas, and optionally a liquid hydrocarbon. Also provided herein are methods of making the carboxy alkyl ester compound.

公开(公告)号：US10259969B2

公开(公告)日：2019-04-16

申请号：US16110372

申请日：2018-08-23

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Bhalchandra S. Lele ,  Eric Allgaier ,  Robert Pervere ,  Jeremy Lyons ,  Steve St-Onge

IPC分类号： C09D133/26 ,  C07C233/20 ,  C09D133/24 ,  C09D123/08 ,  G01N33/82 ,  C08F2/06 ,  C08F230/02 ,  G01N33/78 ,  C08F220/58

摘要： A composition for use as an assay reagent includes a paramagnetic solid support comprising a coating of a synthetic copolymer. The synthetic copolymer comprises two or three of a first copolymerized monomer, a second copolymerized monomer and a third copolymerized monomer and further comprises a polyethylenic backbone.

公开(公告)号：US09839687B2

公开(公告)日：2017-12-12

申请号：US14799666

申请日：2015-07-15

申请人： Suzhou M-conj Biotech Co., Ltd ,  Robert Yongxin Zhao

发明人： Robert Yongxin Zhao

IPC分类号： C07D417/14 ,  C07D413/14 ,  C07D407/14 ,  C07D403/14 ,  C07D309/14 ,  C07C237/52 ,  C07C233/20 ,  C07C59/76 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61K47/48 ,  C07D207/46 ,  C07D407/12 ,  C07D413/04 ,  C07D417/12 ,  C07D493/04 ,  C07D498/14 ,  C07D277/56 ,  C07D519/00 ,  A61K39/00

CPC分类号： A61K47/6803 ,  A61K31/337 ,  A61K31/404 ,  A61K31/537 ,  A61K31/5517 ,  A61K38/05 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61K2039/505 ,  C07C59/76 ,  C07C233/20 ,  C07C237/52 ,  C07D207/46 ,  C07D277/56 ,  C07D309/14 ,  C07D403/14 ,  C07D407/12 ,  C07D407/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D493/04 ,  C07D498/14 ,  C07D519/00 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  G01N33/5014 ,  Y02A50/473

摘要： The present invention relates to novel acetylenedicarboxyl linkers used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

公开(公告)号：US20170226050A1

公开(公告)日：2017-08-10

申请号：US15502342

申请日：2015-08-07

申请人： Andriy Voronov ,  Ihor Tarnavchyk

发明人： Andriy Voronov ,  Ihor Tarnavchyk

IPC分类号： C07C233/20 ,  C08F220/58 ,  C09D133/26 ,  C07C231/12

CPC分类号： C07C233/20 ,  C07C231/12 ,  C08F220/58 ,  C09D133/24 ,  C09D133/26 ,  C08F212/08 ,  C08F220/14 ,  C08F218/08 ,  C08F2220/286

摘要： The invention provides a bio-based acrylic monomer, particularly a plant oil-based acrylic monomer, which is well-suited for emulsion polymerization and latex formation in aqueous medium. Polymers and copolymers formed from the bio-based acrylic monomer are also provided. The invention further provided methods for making the monomer from bio-based triglycerides or fatty esters.

公开(公告)号：US09714328B2

公开(公告)日：2017-07-25

申请号：US14036619

申请日：2013-09-25

申请人： SUMITOMO BAKELITE COMPANY LIMITED ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： Hideyuki Shimaoka ,  Shinichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Jun-ichi Furukawa

IPC分类号： C08G63/48 ,  C08J3/24 ,  C07C233/20 ,  C07C281/02 ,  C08F8/30 ,  G01N33/53 ,  C08F122/38 ,  C07C271/08 ,  C08F222/10 ,  G01N30/02 ,  G01N30/88

CPC分类号： C08J3/24 ,  C07C233/20 ,  C07C271/08 ,  C07C281/02 ,  C08F8/30 ,  C08F122/38 ,  C08F2222/1013 ,  G01N33/5308 ,  G01N2030/027 ,  G01N2030/8813 ,  G01N2030/8836 ,  Y02P20/55 ,  Y10T428/2982 ,  C08F220/60

摘要： The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.

公开(公告)号：US09334352B2

公开(公告)日：2016-05-10

申请号：US14668474

申请日：2015-03-25

申请人： FUJIFILM Corporation

发明人： Ayumi Someya ,  Masataka Yoshizawa ,  Tatsuhiko Obayashi ,  Hiroyuki Naitou

IPC分类号： C08F2/46 ,  C08G61/04 ,  C08F222/20 ,  C07C69/54 ,  C08F220/30 ,  G02B1/04 ,  C08F222/10 ,  C07C13/66 ,  C07D311/96 ,  C07D333/78 ,  C07D263/52 ,  C07D277/60 ,  C07D209/58 ,  C07D307/77 ,  C07C323/19 ,  C07C323/66 ,  C07C233/20 ,  C07C69/602 ,  C08F212/34 ,  C08F12/26 ,  C08F12/32 ,  C08F12/34 ,  C08F212/32 ,  C09D125/16

CPC分类号： C08F222/20 ,  C07C13/66 ,  C07C69/54 ,  C07C69/602 ,  C07C233/20 ,  C07C323/19 ,  C07C323/66 ,  C07C2103/40 ,  C07C2103/52 ,  C07C2603/40 ,  C07C2603/52 ,  C07D209/58 ,  C07D263/52 ,  C07D277/60 ,  C07D307/77 ,  C07D311/96 ,  C07D333/78 ,  C08F12/26 ,  C08F12/32 ,  C08F12/34 ,  C08F212/32 ,  C08F212/34 ,  C08F220/30 ,  C08F222/1006 ,  C09D125/16 ,  G02B1/041 ,  C08L45/00 ,  C08F2222/205

摘要： A curable resin composition containing a compound of formula (1), a compound of formula (2) and a thermal- or photo-radical polymerization initiator is capable of producing a cured product having a low Abbe's number and capable of realizing burr reduction in molding the composition. Ar1 to Ar4 represent aryl or heteroaryl, at least one of Ar1 to Ar4 is aromatic condensed ring, and two or more of Ar1 to Ar4 have a polymerizable group, and at least one of R21 to R26 forms a ring, or at least two bond to each other to form a ring:

摘要翻译： 含有式（1）化合物，式（2）化合物和热或光自由基聚合引发剂的固化性树脂组合物能够生产具有低阿贝数的固化产物，并且能够实现成型中的毛刺减少 组成。 Ar 1〜Ar 4表示芳基或杂芳基，Ar 1〜Ar 4中的至少一个为芳香族稠合环，Ar 1〜Ar 4中的2个以上具有聚合性基团，R 21〜R 26中的至少一个为环，或至少2个以上 彼此形成一个戒指：