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1.发明授权Substituted N-(4-cyano-1H-pyrazol-3-yl)methylamine derivatives, preparation thereof and therapeutic use thereof 失效取代的N-（4-氰基-1H-吡唑-3-基）甲胺衍生物，其制备及其治疗用途公开(公告)号：US08088797B2
公开(公告)日：2012-01-03
申请号：US12490735
申请日：2009-06-24
IPC分类号： A01N43/40
CPC分类号： C07D231/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
摘要翻译： 本发明涉及对应于式（I）的化合物：其中X，R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及这些化合物的制备和治疗用途。
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2.发明申请SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 失效取代的N-（4-氰基-1H-吡唑-3-基）甲基胺衍生物，其制备方法及其治疗方法公开(公告)号：US20100041709A1
公开(公告)日：2010-02-18
申请号：US12490735
申请日：2009-06-24
IPC分类号： A61K31/415 , C07D231/14 , C07D401/12 , C07D403/12 , A61K31/4439 , A61K31/4155 , A61P3/00 , A61P3/04 , A61P3/10 , A61P25/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P37/00 , A61P25/28 , A61P25/16 , A61P25/34
CPC分类号： C07D231/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
摘要翻译： 本发明涉及对应于式（I）的化合物：其中X，R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及这些化合物的制备和治疗用途。
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![Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics](/abs-image/US/2007/11/20/US07297710B1/abs.jpg.150x150.jpg)
3.发明授权Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics 失效N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其制备及其在治疗中的应用公开(公告)号：US07297710B1
公开(公告)日：2007-11-20
申请号：US11457014
申请日：2006-07-12
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译： 本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 3， 4和R 5 5如本文所述。 本发明还涉及所述化合物的制备方法及其在治疗中的应用。
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4.发明申请4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof 有权4-氰基吡唑-3-甲酰胺衍生物，其制备及应用公开(公告)号：US20060135776A1
公开(公告)日：2006-06-22
申请号：US11315774
申请日：2005-12-22
IPC分类号： A61K31/454 , A61K31/4152 , C07D403/02 , C07D231/14 , C07D231/54
CPC分类号： C07D401/12 , C07D231/14
摘要： The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
摘要翻译： 本发明涉及式（I）的4-氰基吡唑-3-甲酰胺衍生物：其中R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8是 如本文所述。 还公开并要求保护的是式（I）化合物的制备和治疗应用的方法。
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5.发明授权4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof 有权4-氰基吡唑-3-甲酰胺衍生物，的制备和应用公开(公告)号：US07521471B2
公开(公告)日：2009-04-21
申请号：US11832146
申请日：2007-08-01
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D401/12 , C07D231/14
摘要： The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
摘要翻译： 本发明涉及式（I）的4-氰基吡唑-3-甲酰胺衍生物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8如本文所述。 还公开并要求保护的是式（I）化合物的制备和治疗应用的方法。
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![DERIVATIVES OF N-[(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL] SULFONAMIDE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS](/abs-image/US/2008/03/20/US20080070962A1/abs.jpg.150x150.jpg)
6.发明申请DERIVATIVES OF N-[(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL] SULFONAMIDE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS 失效N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其在治疗中的应用公开(公告)号：US20080070962A1
公开(公告)日：2008-03-20
申请号：US11859010
申请日：2007-09-21
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61P43/00
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译： 本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 3， 4和R 5 5如本文所述。 本发明还涉及所述化合物的制备方法及其在治疗中的应用。
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![Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics](/abs-image/US/2011/01/25/US07875646B2/abs.jpg.150x150.jpg)
7.发明授权Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics 失效N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其制备及其在治疗中的应用公开(公告)号：US07875646B2
公开(公告)日：2011-01-25
申请号：US11859010
申请日：2007-09-21
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译： 本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 4和R 5如本文所述。 本发明还涉及所述化合物的制备方法及其在治疗中的应用。
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8.发明授权Derivatives of N′-(1,5-diphenyl-1H-pyrazol-3-yl) sulfonamide with CB1 receptor affinity 有权具有CB1受体亲和力的N' - （1,5-二苯基-1H-吡唑-3-基）磺酰胺的衍生物公开(公告)号：US07294645B2
公开(公告)日：2007-11-13
申请号：US11428928
申请日：2006-07-06
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D409/12 , C07D413/14
摘要： The invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 are as defined herein. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， >如本文所定义。 本发明还涉及其制备方法及其在治疗中的应用。
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9.发明授权4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof 有权4-氰基吡唑-3-甲酰胺衍生物，其制备及应用公开(公告)号：US07282516B2
公开(公告)日：2007-10-16
申请号：US11315774
申请日：2005-12-22
IPC分类号： A61K31/4155 , A61K31/454 , C07D231/16
CPC分类号： C07D401/12 , C07D231/14
摘要： The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
摘要翻译： 本发明涉及式（I）的4-氰基吡唑-3-甲酰胺衍生物：其中R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8是 如本文所述。 还公开并要求保护的是式（I）化合物的制备和治疗应用的方法。
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10.发明授权公开(公告)号：US08680102B2
公开(公告)日：2014-03-25
申请号：US12942780
申请日：2010-11-09
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译： 本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。
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