公开(公告)号：US09963430B2

公开(公告)日：2018-05-08

申请号：US14968088

申请日：2015-12-14

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Mogili Narsingam ,  Bandi Vamsi Krishna

IPC分类号： C07D213/02 ,  C07D213/79 ,  C07D213/82 ,  C07C231/02 ,  C07D213/14

CPC分类号： C07D213/82 ,  C07C231/02 ,  C07D213/14 ,  C07D213/69 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D309/40 ,  C07D498/12

摘要： The present invention provides a novel processes for preparation of methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyiridine-2-carboxylate using novel intermediates.

公开(公告)号：US20150232435A1

公开(公告)日：2015-08-20

申请号：US14434202

申请日：2013-10-11

申请人： SOUTHERN RESEARCH INSTITUTE

发明人： Subramaniam Ananthan

IPC分类号： C07D295/13 ,  C07D215/06 ,  C07D239/30 ,  C07D239/74 ,  C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D211/60 ,  C07D471/04 ,  C07D239/26 ,  C07D401/04

CPC分类号： C07D487/04 ,  C07D211/60 ,  C07D213/14 ,  C07D215/06 ,  C07D215/38 ,  C07D215/46 ,  C07D239/26 ,  C07D239/30 ,  C07D239/42 ,  C07D239/74 ,  C07D295/033 ,  C07D295/13 ,  C07D295/215 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04

摘要： Provided are compounds represented by the formula: with Y, Ri, and R2 being defined in the present disclosure; pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors and are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.

摘要翻译： 本发明提供了由下式表示的化合物：其中Y，R 1和R 2定义在本发明中; 其药学上可接受的盐，其氘代形式，其异构体，其溶剂合物，及其混合物。 该化合物可用于治疗患有能够用多巴胺D2 / D3受体的部分激动剂或拮抗剂治疗的病症的患者，并且特别适用于患有精神分裂症，沮丧，神经变性疾病如帕金森病，运动障碍，物质 滥用和复发药物滥用和成瘾物质如可卡因，甲基苯丙胺，尼古丁和酒精，青光眼，认知障碍，不宁腿综合征，注意缺陷多动障碍，高催乳素血症，自闭症，运动障碍如静坐，严重，肌张力障碍以及 各种尿路疾病和其他神经系统疾病。 还提供了制备本发明化合物的方法。

公开(公告)号：US20130281700A1

公开(公告)日：2013-10-24

申请号：US13918735

申请日：2013-06-14

申请人： Zoltán DALICZEK ,  Tibor SOÓS ,  Zoltán FINTA ,  Géza Timári ,  Gábor Vlád

发明人： Zoltán DALICZEK ,  Tibor SOÓS ,  Zoltán FINTA ,  Géza Timári ,  Gábor Vlád

IPC分类号： B01J31/24 ,  C07C17/26 ,  C07C201/12 ,  C07C41/30 ,  C07C2/88 ,  C07D217/18 ,  C07D209/08 ,  C07D217/02 ,  C07D213/127 ,  C07D213/30 ,  C07D295/023 ,  C07D217/20

CPC分类号： B01J31/2404 ,  B01J31/2409 ,  B01J31/2447 ,  C07B35/02 ,  C07B37/04 ,  C07C2/66 ,  C07C2/88 ,  C07C15/52 ,  C07C15/54 ,  C07C17/26 ,  C07C41/30 ,  C07C201/12 ,  C07C205/06 ,  C07D209/08 ,  C07D213/127 ,  C07D213/14 ,  C07D213/26 ,  C07D213/30 ,  C07D215/06 ,  C07D215/12 ,  C07D215/14 ,  C07D217/02 ,  C07D217/16 ,  C07D217/18 ,  C07D217/20 ,  C07D295/023

摘要： The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.

摘要翻译： 本发明涉及式（I）的钯（0） - 三（三 - [3,5-双（三氟甲基） - 苯基] - 膦}络合物，以及其制备和用途。 该化合物稳定，可用作催化剂，效果优异。

公开(公告)号：US20090291989A1

公开(公告)日：2009-11-26

申请号：US12307724

申请日：2007-07-06

申请人： Arkady Mustaev ,  Natalia Kurepina

发明人： Arkady Mustaev ,  Natalia Kurepina

IPC分类号： A61K31/44 ,  A23L3/3463 ,  A23L3/34 ,  C12N5/02 ,  A61K31/415 ,  A61K31/405 ,  A61K31/16 ,  C07D213/53 ,  C07D235/00 ,  C07D209/04 ,  C07C249/00

CPC分类号： C07D213/14 ,  C07C331/20 ,  C07C331/30 ,  C07D209/14 ,  C07D233/64

摘要： Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

摘要翻译： 本文提供了用于抑制各种微生物病原体（包括细菌，真菌，原生动物和病毒病原体）的生长的物质及其药物组合物的组合物。 本文还提供了用组合物治疗微生物疾病/感染和癌症的方法。 通过抑制微生物生长，组合物另外可用于木材保存和食品保存。

公开(公告)号：US3428640A

公开(公告)日：1969-02-18

申请号：US3428640D

申请日：1965-10-11

申请人： PENNSALT CHEMICALS CORP

发明人： MAILEY EVERETT A

IPC分类号： C07D213/14 ,  C07D213/61 ,  C07D31/02

CPC分类号： C07D213/14 ,  C07D213/61

公开(公告)号：US3072662A

公开(公告)日：1963-01-08

申请号：US79730359

申请日：1959-03-04

申请人： UNION CARBIDE CORP

发明人： MURRAY JR JAMES V ,  FOSTER DONALD J

IPC分类号： C07D213/14

CPC分类号： C07D213/14

公开(公告)号：US2067704A

公开(公告)日：1937-01-12

申请号：US63819532

申请日：1932-10-17

申请人： UNION OIL CO

发明人： BAILEY JAMES R

IPC分类号： C07D213/14 ,  C07D215/04

CPC分类号： C07D213/14 ,  C07D215/04

公开(公告)号：US20240025858A1

公开(公告)日：2024-01-25

申请号：US18257373

申请日：2021-12-15

申请人： GW Research Limited

发明人： Alan James SILCOCK ,  Antoine MILLET ,  Karen Ka-Yen TSE ,  Paul Stuart HINCHLIFFE ,  Andrew SHARPE ,  Iain David SIMPSON ,  Joanne PEACH ,  Stefano LEVANTO

IPC分类号： C07D231/12 ,  C07C39/23 ,  C07D249/06 ,  C07D239/34 ,  C07D213/65 ,  C07D213/74 ,  C07D213/16 ,  C07D213/14 ,  C07D405/04 ,  C07D263/32 ,  C07D249/08 ,  C07D261/08 ,  C07D233/64 ,  C07D271/10 ,  C07D213/64 ,  C07D405/06 ,  C07C215/50 ,  C07C213/08 ,  C07C43/23 ,  C07C41/30 ,  C07D271/06 ,  A61P25/08

CPC分类号： C07D231/12 ,  C07C39/23 ,  C07D249/06 ,  C07D239/34 ,  C07D213/65 ,  C07D213/74 ,  C07D213/16 ,  C07D213/14 ,  C07D405/04 ,  C07D263/32 ,  C07D249/08 ,  C07D261/08 ,  C07D233/64 ,  C07D271/10 ,  C07D213/64 ,  C07D405/06 ,  C07C215/50 ,  C07C213/08 ,  C07C43/23 ,  C07C41/30 ,  C07D271/06 ,  A61P25/08

摘要： The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of novel cannabidiol compounds.

公开(公告)号：US20190192535A1

公开(公告)日：2019-06-27

申请号：US16145768

申请日：2018-09-28

申请人： Enanta Pharmaceuticals, Inc.

发明人： Brian C. Shook ,  In Jong Kim ,  Thomas P. Blaisdell ,  Jianming Yu ,  Joseph Panarese ,  Kai Lin ,  Michael H.J. Rhodin ,  Nicole V. McAllister ,  Yat Sun Or

IPC分类号： A61K31/5513 ,  A61P31/14

CPC分类号： A61K31/5513 ,  A61K31/4439 ,  A61K31/7056 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  A61P31/14 ,  C07D213/12 ,  C07D213/14 ,  C07D217/12 ,  C07D217/14 ,  C07D243/24 ,  C07D403/12 ,  C07D491/04 ,  C07D498/08 ,  C07K16/1027 ,  C07K2317/24 ,  C07K2317/76 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

公开(公告)号：US09969743B2

公开(公告)日：2018-05-15

申请号：US15463051

申请日：2017-03-20

申请人： Southern Research Institute

发明人： Subramaniam Ananthan

IPC分类号： C07D487/04 ,  C07D295/15 ,  C07D239/42 ,  C07D215/46 ,  C07D213/14 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D215/38 ,  C07D295/215 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D211/60 ,  C07D213/14 ,  C07D215/06 ,  C07D215/38 ,  C07D215/46 ,  C07D239/26 ,  C07D239/30 ,  C07D239/42 ,  C07D239/74 ,  C07D295/033 ,  C07D295/13 ,  C07D295/215 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04

摘要： Provided are compounds represented by the formula: In which: Y is an unbranched, saturated or unsaturated hydrocarbon chain with 2-5 hydrocarbon atoms R1=aryl R2=NR3R4 wherein R3 and R4 together form a heterocycle or R2=4-substitutedcyclohexyl, 1-substitutedpiperidine-4-yl or imidazo(1,2-a)azine-2-yl when Y is as defined above and R1 is a heterocycle other than benzothiophene pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition that is capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors. The compounds are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.