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    Composite Materials Loaded with Therapeutic and Diagnostic Agents Comprising Polymer Nanoparticles and Polymer Fibers
    3.
    发明申请
    Composite Materials Loaded with Therapeutic and Diagnostic Agents Comprising Polymer Nanoparticles and Polymer Fibers 审中-公开
    由聚合物纳米颗粒和聚合物纤维组成的包含治疗和诊断剂的复合材料

    公开(公告)号：US20120148493A1

    公开(公告)日：2012-06-14

    申请号：US13256872

    申请日：2010-03-16

    申请人： Thomas Schmehl ,  Juliane Nguyen ,  Moritz Beck-Broichsitter ,  Tobias Gessler ,  Thomas Kissel ,  Marcel Thieme

    发明人： Thomas Schmehl ,  Juliane Nguyen ,  Moritz Beck-Broichsitter ,  Tobias Gessler ,  Thomas Kissel ,  Marcel Thieme

    IPC分类号： A61K9/70 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P35/00 ,  A61P17/00 ,  A61P17/02 ,  D01D5/00 ,  A61K49/00 ,  A61P3/00 ,  B82Y5/00

    CPC分类号： A61K9/5153 ,  A61K9/70

    摘要： The invention relates to composite materials comprising polymer nanofibers and polymer nanoparticles, wherein at least one of the two polymer materials is loaded with a substance selected from therapeutic and diagnostic agents. Fibers and nanoparticles can comprise identical or different polymers; the polymer materials are, however, biocompatible in every case. Therapeutic and diagnostic agents can be hydrophilic or lipophilic and the two polymer materials likewise. The at least one polymer material and the substance with which said material is loaded are either both hydrophilic or both lipophilic. The polymer nanoparticles of the composite materials have a diameter of 10 nm to 600 nm. The polymer fibers have diameters of 10 nm to 50 μm and lengths of 1 μm to several meters. The invention further relates to a method for producing said composite materials. Polymer nanoparticles can be produced in different ways, such as through controlled precipitation of a polymer solution that optionally comprises a loading substance. The nanoparticles are then mixed with another polymer and a loading substance as applicable, depending on whether particles, fibers or both are to be loaded with substance. The processing of this solution into composites comprising polymer fibers polymer nanoparticles can occur by means of electrospinning, melt spinning, extruding or template process. Composite materials according to the invention are suitable for the production of pharmaceuticals that release therapeutically or diagnostically effective substances slowly and in a controlled manner.

    摘要翻译： 本发明涉及包含聚合物纳米纤维和聚合物纳米颗粒的复合材料，其中两种聚合物材料中的至少一种负载有选自治疗剂和诊断剂的物质。 纤维和纳米颗粒可以包含相同或不同的聚合物; 然而，聚合物材料在每种情况下都是生物相容的。 治疗和诊断剂可以是亲水的或亲脂的，并且两种聚合物材料同样。 所述至少一种聚合物材料和所述材料被加载的物质既是亲水的，也是亲油的。 复合材料的聚合物纳米颗粒具有10nm至600nm的直径。 聚合物纤维的直径为10nm〜50μm，长度为1〜数米。 本发明还涉及一种生产所述复合材料的方法。 聚合物纳米颗粒可以以不同的方式制备，例如通过可选地包含负载物质的聚合物溶液的可控沉淀。 然后将纳米颗粒与另一种聚合物和负载物质混合，这取决于颗粒，纤维或两者是否被装载物质。 将该溶液加工成包含聚合物纤维聚合物纳米颗粒的复合材料可以通过静电纺丝，熔融纺丝，挤出或模板方法进行。 根据本发明的复合材料适用于缓慢地并以受控方式释放治疗或诊断有效物质的药物。