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公开(公告)号：US20100227800A1
公开(公告)日：2010-09-09
申请号：US12438662
申请日：2007-08-30
申请人： Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
发明人： Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
IPC分类号： A61K38/13 , C07D471/04 , A61K31/437 , A61P11/02 , A61P3/10 , A61P17/06 , A61P37/06 , A61P29/00 , A61P19/02 , A61P1/04 , A61K31/506 , A61K31/56 , A61K31/436
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译： 本发明涉及式（I）化合物; 其中X和R 1至R 5具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂，特别是Itk或PI3K的抑制剂，用于治疗或预防免疫学，炎症或过敏性疾病。 本发明还涉及药物组合物，包括所述化合物，这些化合物的制备以及生产和用作药物。
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公开(公告)号：US08883820B2
公开(公告)日：2014-11-11
申请号：US12438662
申请日：2007-08-30
申请人： Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
发明人： Francis Wilson , Nigel Ramsden , Kathryn Bell , Andrew Cansfield , Svenja Burckhardt , Jess Taylor , Mihiro Sunose , David Middlemiss
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译： 本发明涉及式（I）化合物; 其中X和R 1至R 5具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂，特别是Itk或PI3K的抑制剂，用于治疗或预防免疫学，炎症或过敏性疾病。 本发明还涉及药物组合物，包括所述化合物，这些化合物的制备以及生产和用作药物。
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公开(公告)号：US08865699B2
公开(公告)日：2014-10-21
申请号：US12744940
申请日：2008-11-21
申请人： Nigel Ramsden , Kathryn Bell , Andrew David Cansfield , Jess Taylor , Mihiro Sunose , David Middlemiss , Gitte Neubauer
发明人： Nigel Ramsden , Kathryn Bell , Andrew David Cansfield , Jess Taylor , Mihiro Sunose , David Middlemiss , Gitte Neubauer
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) wherein X, T1 and R1 to R3 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译： 本发明涉及式（I）的化合物，其中X，T1和R1至R3具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂，特别是用于治疗或预防免疫学，炎症，自身免疫或过敏性疾病的PI3K抑制剂。 本发明还涉及药物组合物，包括所述化合物，这些化合物的制备以及生产和用作药物。
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公开(公告)号：US20110021497A1
公开(公告)日：2011-01-27
申请号：US12744940
申请日：2008-11-21
申请人： Nigel Ramsden , Kathryn Bell , Andrew David Cansfield , Jess Taylor , Mihiro Sunose , David Middlemiss , Gitte Neubauer
发明人： Nigel Ramsden , Kathryn Bell , Andrew David Cansfield , Jess Taylor , Mihiro Sunose , David Middlemiss , Gitte Neubauer
IPC分类号： A61K31/437 , C07D471/04 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/506 , A61P37/00 , A61P29/00 , A61P37/08 , A61P37/06 , A61P1/18 , A61P17/00 , A61P17/06 , A61P19/02 , A61P1/00 , A61P3/10 , A61P11/06 , A61P35/00 , A61P25/28 , A61P9/00 , A61P3/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) wherein X, T1 and R1 to R3 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
摘要翻译： 本发明涉及式（I）的化合物，其中X，T1和R1至R3具有在说明书和权利要求书中引用的含义。 所述化合物可用作蛋白激酶抑制剂，特别是用于治疗或预防免疫学，炎症，自身免疫或过敏性疾病的PI3K抑制剂。 本发明还涉及药物组合物，包括所述化合物，这些化合物的制备以及生产和用作药物。
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5.发明授权Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins 失效用于鉴定磷脂酰肌醇激酶相互作用分子和用于纯化磷脂酰肌醇激酶蛋白的方法公开(公告)号：US08367830B2
公开(公告)日：2013-02-05
申请号：US13321122
申请日：2010-05-14
IPC分类号： C07D471/04 , C08B37/00 , G01N33/573
CPC分类号： C07D471/04 , B01J20/3212 , B01J20/3255 , C12N9/1205 , C12N11/06 , C12Q1/485 , G01N2500/02
摘要： The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.
摘要翻译： 本发明涉及式（I）的固定化合物，其固定产物及其制备方法以及用于鉴定磷脂酰肌醇激酶相互作用化合物或用于纯化或鉴定磷脂酰肌醇激酶蛋白的方法和用途。
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公开(公告)号：US09242987B2
公开(公告)日：2016-01-26
申请号：US13503083
申请日：2010-10-19
申请人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
发明人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P37/08 , A61P41/00 , A61K31/541 , A61K31/5386 , A61K31/5377 , A61K31/496
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译： 本发明涉及式（I）的化合物，其中X 1至X 5，Y，Z 1至Z 3和R具有在说明书和权利要求书中引用的含义。 所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。
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公开(公告)号：US20120252779A1
公开(公告)日：2012-10-04
申请号：US13503083
申请日：2010-10-19
申请人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe
发明人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe
IPC分类号： A61K31/519 , A61K31/5386 , A61K31/5377 , A61K31/496 , A61P41/00 , C07D487/04 , A61P37/00 , A61P29/00 , A61P37/08 , A61K31/541 , C07D498/08
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译： 本发明涉及式（I）的化合物，其中X 1至X 5，Y，Z 1至Z 3和R具有在说明书和权利要求书中引用的含义。 所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。
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8.发明申请METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS 失效磷脂酰肌氨酸激酶相互作用分子鉴定方法和磷脂酰肌氨酸激酶蛋白的纯化方法公开(公告)号：US20120135421A1
公开(公告)日：2012-05-31
申请号：US13321122
申请日：2010-05-14
IPC分类号： G01N33/573 , C08B37/00 , C07D471/04
CPC分类号： C07D471/04 , B01J20/3212 , B01J20/3255 , C12N9/1205 , C12N11/06 , C12Q1/485 , G01N2500/02
摘要： The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.
摘要翻译： 本发明涉及式（I）的固定化合物，其固定产物及其制备方法以及用于鉴定磷脂酰肌醇激酶相互作用化合物或用于纯化或鉴定磷脂酰肌醇激酶蛋白的方法和用途。
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9.发明申请公开(公告)号：US20130190292A1
公开(公告)日：2013-07-25
申请号：US13816555
申请日：2011-08-12
申请人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
发明人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
IPC分类号： C07D487/04 , C07D491/107 , C07D498/08
CPC分类号： C07D487/04 , A61K31/519 , C07D491/107 , C07D498/08 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译： 本发明涉及其中X1至X5，Y，Z1至Z3和R具有在说明书和权利要求书中引用的含义的式（I）化合物。 所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。
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10.发明授权公开(公告)号：US09040545B2
公开(公告)日：2015-05-26
申请号：US13816555
申请日：2011-08-12
申请人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
发明人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D519/00 , C07D491/107 , C07D498/08
CPC分类号： C07D487/04 , A61K31/519 , C07D491/107 , C07D498/08 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译： 本发明涉及其中X1至X5，Y，Z1至Z3和R具有在说明书和权利要求书中引用的含义的式（I）化合物。 所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。
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