公开(公告)号：US20240317671A1

公开(公告)日：2024-09-26

申请号：US18731457

申请日：2024-06-03

Applicant: Buck Institute for Research on Aging

Inventor： Scott Michael ULRICH

IPC: C07C69/675 ,  A61P3/04 ,  C12N9/20 ,  C12N11/06 ,  C12N11/087 ,  C12P7/42 ,  C12P7/52 ,  C12P7/62 ,  C12P41/00

CPC classification number: C07C69/675 ,  A61P3/04 ,  C12N9/20 ,  C12P7/42 ,  C12P7/52 ,  C12P7/62 ,  C12P41/003 ,  C12N11/06 ,  C12N11/087

Abstract: In various embodiments methods of preparing hydroxybutyryl 3-hydroxybutyrate and related compounds are provided along with methods of use thereof.

公开(公告)号：US12070543B2

公开(公告)日：2024-08-27

申请号：US18323055

申请日：2023-05-24

Applicant: Orth Consulting, LLC

Inventor： Donald S. Orth ,  Roger W. Orth

IPC: A61M1/36 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/14 ,  A61M1/16 ,  A61M1/26 ,  A61M1/34 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/08 ,  B01J20/22 ,  B01J31/00 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00

CPC classification number: A61M1/3687 ,  A61F2/01 ,  A61F2/95 ,  A61K8/66 ,  A61M1/15632 ,  A61M1/1621 ,  A61M1/267 ,  A61M1/3489 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3679 ,  A61M1/3689 ,  B01D15/00 ,  B01D15/08 ,  B01D63/02 ,  B01D63/06 ,  B01D69/04 ,  B01D69/043 ,  B01D69/08 ,  B01J20/22 ,  B01J31/003 ,  C07K16/00 ,  C07K16/38 ,  C07K16/40 ,  C12N11/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/14 ,  C12N11/16 ,  C12N11/18 ,  A61F2/00 ,  A61M2202/0445 ,  A61M2202/0456 ,  A61M2202/046 ,  A61M2202/07 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3303 ,  B01J2220/4812 ,  B01J2220/4868

Abstract: A detoxification method for treating sepsis, microbial infections, and other inflammatory conditions includes the steps of inducing flow of patient blood through a blood treatment device consisting of a bioreactor inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) and extracellular adenosine triphosphate (ATP) contained within patient blood can be irreversibly detoxified by passage of patient blood over a bioreactor surface having attached or immobilized alkaline phosphatase enzymes and acyloxyacyl hydrolase enzyme, with the bioreactor being contained within the blood treatment device. The method uses continuous treatment of a patient's blood to convert LPS and extracellular ATP in blood into inhibitors of inflammation in vivo without adding any chemicals to the bloodstream of the patient.

公开(公告)号：US20240254436A1

公开(公告)日：2024-08-01

申请号：US18426809

申请日：2024-01-30

Applicant: Alma Mater Studiorum - Università di Bologna

Inventor： Stefania RAPINO ,  Francesco ZERBETTO ,  Gastone CASTELLANI ,  Stefano SALVIOLI ,  Beatrice FRABONI ,  Isabella ZIRONI ,  Maria CONTE ,  Claudio FRANCESCHI ,  Daniela SALVATORE ,  Maila BECCONI

IPC: C12N5/00 ,  C12N5/09 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/08 ,  C12N11/04 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089 ,  C12N11/12 ,  G01N33/50

CPC classification number: C12N5/0018 ,  C12N5/0068 ,  C12N5/0693 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0036 ,  C12N9/0053 ,  C12N9/0061 ,  C12N9/0065 ,  C12N9/0069 ,  C12N9/0093 ,  C12N11/04 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089 ,  C12N11/12 ,  C12Y101/03004 ,  C12Y106/03001 ,  C12Y109/03001 ,  C12Y110/03002 ,  C12Y111/01006 ,  C12Y113/12004 ,  C12Y117/03002 ,  G01N33/5008 ,  C12N2500/02 ,  C12N2501/71 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2533/76 ,  C12N2533/78 ,  C12N2533/80 ,  C12N2537/10

Abstract: The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.

公开(公告)号：US11911357B2

公开(公告)日：2024-02-27

申请号：US17332194

申请日：2021-05-27

Applicant: Alcresta Therapeutics, Inc.

Inventor： Robert Gallotto ,  Greta L. Loring ,  Kenneth Gary ,  Edward S. Park ,  David J. Brown ,  Willem Robert Klaas Schoevaart ,  Michiel Christian Alexander van Vliet

IPC: A23L33/00 ,  C12N9/20 ,  A61K31/202 ,  A61L29/04 ,  A61M5/14 ,  A61M5/142 ,  C12N11/06 ,  A61J15/00 ,  A23L33/12 ,  C12N11/087 ,  C12N11/089

CPC classification number: A61K31/202 ,  A23L33/00 ,  A23L33/12 ,  A23L33/40 ,  A61J15/0076 ,  A61L29/048 ,  A61M5/14 ,  A61M5/142 ,  A61M5/1413 ,  C12N9/20 ,  C12N11/06 ,  C12N11/087 ,  C12N11/089

Abstract: Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

公开(公告)号：US11905548B2

公开(公告)日：2024-02-20

申请号：US17881175

申请日：2022-08-04

Applicant: Waters Technologies Corporation

Inventor： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

IPC: C12Q1/37 ,  C12N11/06 ,  C12N11/14 ,  C12M1/40 ,  C12M1/34 ,  C12Q1/48

CPC classification number: C12Q1/37 ,  C12M21/18 ,  C12M41/40 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/48

Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

公开(公告)号：US20230340296A1

公开(公告)日：2023-10-26

申请号：US18070870

申请日：2022-11-29

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

Inventor： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC: C09D189/00 ,  C12N9/14 ,  C12N9/20 ,  C09D7/40 ,  C09D5/16 ,  C12N11/06 ,  C12N9/54 ,  C12N9/96 ,  C12N9/26 ,  C08G65/333 ,  C09D5/02 ,  A61K47/60 ,  C12N11/089 ,  C09D175/16

CPC classification number: C09D189/00 ,  A61K47/60 ,  C08G65/33337 ,  C09D5/024 ,  C09D5/16 ,  C09D7/40 ,  C09D175/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/2408 ,  C12N9/2411 ,  C12N9/54 ,  C12N9/96 ,  C12N11/06 ,  C12N11/089 ,  C08L2203/02 ,  C08L2205/02

Abstract: Bioactive coatings are provided with two component solvent borne resin and an enzyme dispersed therein. The unique coatings provide for enzyme dispersion in the two component solvent borne resin in aggregates with small particle sizes of up to 5 micrometers. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

公开(公告)号：US20230212426A1

公开(公告)日：2023-07-06

申请号：US18069508

申请日：2022-12-21

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  Toyota Motor Corporation ,  Regents of the University of Minnesota

Inventor： Hongfei Jia ,  Ping Wang ,  Liting Zhang ,  Andreas Buthe ,  Xueyan Zhao ,  Songtao Wu ,  Masahiko Ishii ,  Minjuan Zhang

IPC: C09D189/00 ,  C09D5/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/26 ,  C12N9/54 ,  C12N9/96 ,  C08G65/333 ,  C09D5/02 ,  A61K47/60 ,  C09D7/40 ,  C12N11/089 ,  C12N11/06 ,  C09D175/16

CPC classification number: C09D189/00 ,  C09D5/16 ,  C12N9/14 ,  C12N9/20 ,  C12N9/2411 ,  C12N9/54 ,  C12N9/96 ,  C12N9/2408 ,  C08G65/33337 ,  C09D5/024 ,  A61K47/60 ,  C09D7/40 ,  C12N11/089 ,  C12N11/06 ,  C09D175/16 ,  C08L2203/02 ,  C08L2205/02

Abstract: A process of stabilizing the activity of an enzyme against inactivation by water weathering are provided including associating one or more polymeric moieties of a polyoxyethylene having a molecular weight of 10,000 Daltons or greater with an enzyme to form a chemically modified enzyme; and dispersing said chemically modified enzyme in a base to form a water-stabilized active coating material.

公开(公告)号：US10059977B2

公开(公告)日：2018-08-28

申请号：US15484781

申请日：2017-04-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kelvin J. Witcher ,  William E. Foltz ,  Naiyong Jing

IPC: C12Q1/22

CPC classification number: C12Q1/22 ,  C12N11/06

Abstract: Spore carriers suitable for use in biological indicators are described. The spore carriers include a substrate such as polymeric film or non-woven web with a hydrophilic nanostructured layer bonded to it. Spores are bonded to the nanostructured layer. Nanostructured layers including nanoparticles, such as acid-sintered silica nanoparticles are described. Biological indicators including such spore carriers are also described.

公开(公告)号：US09938378B2

公开(公告)日：2018-04-10

申请号：US14112742

申请日：2012-04-20

Applicant: Donald Wellings

Inventor： Donald Wellings

IPC: C08G69/48 ,  A61L15/32 ,  C08J3/12 ,  C08J3/24 ,  C12N11/02 ,  C12N11/06 ,  A61L26/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  C07H21/00 ,  C07K1/04 ,  C08B37/00 ,  C12N5/00 ,  C12N11/08 ,  C09D177/04

CPC classification number: C08G69/48 ,  A61L15/32 ,  A61L26/0019 ,  A61L26/0047 ,  A61L2300/434 ,  C07H21/00 ,  C07K1/042 ,  C08B37/00 ,  C08J3/126 ,  C08J3/24 ,  C08J2477/00 ,  C09D177/04 ,  C12N5/0018 ,  C12N11/02 ,  C12N11/06 ,  C12N11/08 ,  G01N33/532 ,  G01N33/54313 ,  G01N33/585 ,  Y10T428/249991 ,  Y10T428/2998

Abstract: The invention provides a non-particulate cross-linked poly-ϵ-lysine polymer. The poly-ϵ-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-ϵ-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fiber. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilization of species, cell culturing and in chromatographic separation.

公开(公告)号：US09907854B2

公开(公告)日：2018-03-06

申请号：US15281023

申请日：2016-09-29

Applicant: CellMosaic, Inc.

Inventor： Yumei Huang

IPC: A61K31/7004 ,  A61K47/48 ,  C12N11/06 ,  C07C43/23 ,  C07K17/10 ,  C07K17/14 ,  C07C291/04 ,  C08G65/00 ,  C08G83/00

CPC classification number: A61K47/60 ,  A61K47/54 ,  A61K47/549 ,  A61K47/61 ,  A61K47/62 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6851 ,  C07C43/23 ,  C07C291/04 ,  C07K17/10 ,  C07K17/14 ,  C08G65/00 ,  C08G83/005 ,  C08G83/006 ,  C12N11/06

Abstract: The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (