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公开(公告)号：US20090069368A1
公开(公告)日：2009-03-12
申请号：US12171373
申请日：2008-07-11
申请人： Francoise BONO , Nathalie GUILLO , Jean-Pierre MAFFRAND , Pierre FONS , Jacob-Alsboek OLSEN , Gilles ANNE-ARCHARD
发明人： Francoise BONO , Nathalie GUILLO , Jean-Pierre MAFFRAND , Pierre FONS , Jacob-Alsboek OLSEN , Gilles ANNE-ARCHARD
IPC分类号： A61K31/437 , C07D471/04 , C07D221/04 , A61K31/435 , A61P9/10 , A61P9/00
CPC分类号： C07D519/00 , A61K31/435 , A61K47/55 , C07D209/02 , C07D221/02
摘要： FGF receptor agonist compounds corresponding to the general formula: M1-L-M2 are disclosed in which M1 and M2, which may be identical or different, each represent, independently of one another, a monomer unit M, and L represents a linker group, wherein the monomer unit is of the general formula I.
摘要翻译： 公开了对应于通式M1-L-M2的FGF受体激动剂化合物，其中M1和M2可以相同或不同，各自独立地表示单体单元M，L表示连接基团， 其中单体单元具有通式I。
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2.发明申请Novel 1,2,3-Substituted Indolizine Derivatives, Inhibitors of FGFs, Method for Preparing Them and Pharmaceutical Compositions Containing Them 有权新型1,2,3取代的中氮衍生物，FGF抑制剂，其制备方法和含有它们的药物组合物公开(公告)号：US20090023770A1
公开(公告)日：2009-01-22
申请号：US12198545
申请日：2008-08-26
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00 , A61P9/00
CPC分类号： C07D471/04
摘要： The present invention relates to novel 1,2,3-substituted indolizine derivative which are inhibitors of fibroblast growth factors, to methods or preparing such derivatives, to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising such derivatives.
摘要翻译： 本发明涉及作为成纤维细胞生长因子的抑制剂，方法或制备此类衍生物的新颖的1,2,3-取代的中氮茚衍生物，涉及包含这些衍生物的药物组合物，以及包含这些衍生物的治疗方法。
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3.发明申请USE OF FGF INHIBITING SUBSTITUTED 1,2,3 INDOLIZINE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS WHICH CAN BE USED TO TREAT DISEASES LINKED TO PATHOLOGICAL CHOROIDAL ANGIOGENESIS 有权使用FGF抑制取代的1,2,3位吲哚衍生物在制备可用于治疗与病理性CHOROIDAL血管生成相关的疾病的药物中公开(公告)号：US20090030034A1
公开(公告)日：2009-01-29
申请号：US12201075
申请日：2008-08-29
申请人： Alain BADORC , Francoise BONO , Marie-Francoise BORDES , Jean-Michel FOIDART , Nathalie GUILLO , Agnes NOEL , Jean Marie RAKIC
发明人： Alain BADORC , Francoise BONO , Marie-Francoise BORDES , Jean-Michel FOIDART , Nathalie GUILLO , Agnes NOEL , Jean Marie RAKIC
IPC分类号： A61K31/437 , C07D221/04 , A61P7/00
CPC分类号： A61K31/437
摘要： The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general formula (I):
摘要翻译： 因此本发明涉及1,2,3-取代的中氮茚衍生物在制备用于治疗与病理性脉络膜血管生成相关的疾病的药物中的用途，该衍生物对应于以下通式（I）：
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![Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same](/abs-image/US/2011/06/09/US20110136856A1/abs.jpg.150x150.jpg)
4.发明申请Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same 有权新的咪唑并[1,5-a]吡啶衍生物，其制备方法和含有它们的药物组合物公开(公告)号：US20110136856A1
公开(公告)日：2011-06-09
申请号：US13020883
申请日：2011-02-04
IPC分类号： A61K31/437 , A61K31/444 , A61P35/00 , A61P27/02 , A61P9/00 , A61P9/10 , A61P29/00 , A61P19/00 , A61P3/04
CPC分类号： C07D471/04
摘要： The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the theraprutic uses thereof.
摘要翻译： 本发明涉及式I化合物，制备所述化合物的方法，含有该化合物的药物组合物及其治疗用途。
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5.发明申请DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS 有权7-烷基-1,3-萘二酮的衍生物，其制备方法及其在治疗中的应用公开(公告)号：US20100144782A1
公开(公告)日：2010-06-10
申请号：US12631130
申请日：2009-12-04
申请人： Antoine ALAM , Francoise BONO , Olivier DUCLOS , Gary MCCORT
发明人： Antoine ALAM , Francoise BONO , Olivier DUCLOS , Gary MCCORT
IPC分类号： A61K31/4375 , C07D471/04 , A61P35/00 , A61P17/00 , A61P9/10 , A61P27/02
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）化合物：其中R 1，R 2，R 3和R 4如本公开所定义，含有它们的组合物，其制备方法及其在治疗中的应用。
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6.发明申请DERIVATIVES OF 2-OXOALKYL-1-PIPERAZIN-2-ONE, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME 审中-公开2-氧杂环戊烯-1-哌啶-2-酮的衍生物，其制备方法及其治疗方法公开(公告)号：US20120289518A1
公开(公告)日：2012-11-15
申请号：US13556328
申请日：2012-07-24
IPC分类号： A61K31/496 , A61P25/08 , A61P25/28 , A61P25/16 , A61P25/14 , A61P25/00 , A61P25/18 , A61P25/24 , A61P9/04 , A61P9/10 , A61P27/02 , A61P27/06 , A61P35/00 , A61P35/04 , A61P35/02 , A61P11/00 , A61P37/08 , A61P11/06 , A61P29/00 , A61P37/06 , A61P19/08 , A61P19/10 , C07D211/70
CPC分类号： C07D401/14
摘要： The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.
摘要翻译： 本发明涉及4- {2- [苯基-3,6-二氢吡啶-1-基] -2-氧代烷基} -1-哌嗪-2-酮和4- {2- [苯基-2,5 - 二氢吡咯-1-基] -2-氧代烷基} -1-哌嗪-2-酮，其中A，B，m，R 3和n如本文所定义。 本发明还涉及其制备及其治疗用途。
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7.发明申请DERIVATIVES OF 2-OXOALKYL-1-PIPERAZIN-2-ONE, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME 有权2-氧杂环戊烯-1-哌啶-2-酮的衍生物，其制备方法及其治疗方法公开(公告)号：US20110144122A1
公开(公告)日：2011-06-16
申请号：US12966408
申请日：2010-12-13
IPC分类号： A61K31/496 , C07D401/14 , A61P25/00 , A61P9/00 , A61P27/06 , A61P35/00 , A61P11/06 , A61P29/00 , A61P19/02 , A61P17/06
CPC分类号： C07D401/14
摘要： The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.
摘要翻译： 本发明涉及4- {2- [苯基-3,6-二氢吡啶-1-基] -2-氧代烷基} -1-哌嗪-2-酮和4- {2- [苯基-2,5 - 二氢吡咯-1-基] -2-氧代烷基} -1-哌嗪-2-酮，其中A，B，m，R 3和n如本文所定义。 本发明还涉及其制备及其治疗用途。
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8.发明申请DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALKANONE AND USE THEREOF AS p75 INHIBITORS 有权（BRIDGED PIPERAZINYL）-1-ALKANONE的衍生物及其作为p75抑制剂的用途公开(公告)号：US20110144116A1
公开(公告)日：2011-06-16
申请号：US12966413
申请日：2010-12-13
IPC分类号： A61K31/4995 , C07D403/14 , A61P25/28 , A61P25/24 , A61P25/18 , A61P9/10 , A61P35/00 , A61P35/02 , A61P35/04 , A61P11/06 , A61P37/02 , A61P19/08 , A61P19/10 , A61P19/02
CPC分类号： C07D471/08
摘要： The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.
摘要翻译： 本发明涉及（（苯基）-3,6-二氢吡啶-1-基）（桥连哌嗪基）-1-烷酮衍生物和（（苯基）-2,5-二氢吡咯-1-基）（桥接哌嗪基 ）-1-烷基酮对应于式（I）：其中变量如本文所定义，其制备及其治疗用途。
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9.发明申请DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS 有权7-烷基-1,3-萘二酮的衍生物，其制备方法及其在治疗中的应用公开(公告)号：US20100144757A1
公开(公告)日：2010-06-10
申请号：US12631122
申请日：2009-12-04
申请人： Antoine ALAM , Sandrine BISCARRAT , Isabelle BLANC , Francoise BONO , Olivier DUCLOS , Gary MCCORT
发明人： Antoine ALAM , Sandrine BISCARRAT , Isabelle BLANC , Francoise BONO , Olivier DUCLOS , Gary MCCORT
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/497 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）的7-炔基-1,8-萘啶酮：其中R1，R2，R3和R4如本公开所定义，含有它们的组合物，其制备方法及其用途 在治疗。
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