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公开(公告)号：US20090143357A1
公开(公告)日：2009-06-04
申请号：US11908416
申请日：2006-03-29
申请人： Frank Diaz , Francine S. Farouz , Ryan Coatsworth Holcomb , Edward A. Kesicki , Hua Chee Ooi , Alexander Rudolph , Frank Stappenbeck , Eugene D. Thorsett , John Joseph Gaudino , Kimba Lee Fischer , Adam Wade Cook
发明人： Frank Diaz , Francine S. Farouz , Ryan Coatsworth Holcomb , Edward A. Kesicki , Hua Chee Ooi , Alexander Rudolph , Frank Stappenbeck , Eugene D. Thorsett , John Joseph Gaudino , Kimba Lee Fischer , Adam Wade Cook
IPC分类号： A61K31/553 , C07D267/10 , C07D413/02 , A61K31/5377 , C07D241/02 , A61K31/496 , C07D417/02 , A61K31/541 , A61P35/00
CPC分类号： C07D413/12 , C07D403/12 , C07D417/12
摘要： Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
摘要翻译： 公开了用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的替代的尿素化合物。 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它由DNA复制，染色体分离或细胞分裂缺陷而特征的疾病。
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公开(公告)号：US08093244B2
公开(公告)日：2012-01-10
申请号：US11908416
申请日：2006-03-29
申请人： Frank Diaz , Francine S. Farouz , Ryan Coatsworth Holcomb , Edward A. Kesicki , Kimba Lee Fischer , Adam Wade Cook
发明人： Frank Diaz , Francine S. Farouz , Ryan Coatsworth Holcomb , Edward A. Kesicki , Kimba Lee Fischer , Adam Wade Cook
IPC分类号： A61P35/00 , A61K31/497 , A61K31/5355 , A61K31/541 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D413/12 , C07D403/12 , C07D417/12
摘要： Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
摘要翻译： 公开了用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的替代的尿素化合物。 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它由DNA复制，染色体分离或细胞分裂缺陷而特征的疾病。
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公开(公告)号：US20080318974A1
公开(公告)日：2008-12-25
申请号：US11659389
申请日：2005-08-18
IPC分类号： A61K31/497 , C07D401/12 , A61P35/00 , C07D401/04
CPC分类号： C07D241/20 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
摘要翻译： 公开了可用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的芳基和杂芳基取代的脲化合物。 还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。
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4.发明授权5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts 有权5-（5-（2-（3-氨基丙氧基）-6-甲氧基苯基）-1H-吡唑-3-基氨基）吡嗪-2-甲腈，其药学上可接受的盐，或盐的溶剂合物公开(公告)号：US08314108B2
公开(公告)日：2012-11-20
申请号：US12634725
申请日：2009-12-10
IPC分类号： A61K31/4965
CPC分类号： C07D403/12 , A61K31/4965 , A61K45/06 , A61K2300/00
摘要： The present invention provides an aminopyrazole compound, more particularly, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
摘要翻译： 本发明提供抑制Chk1的氨基吡唑化合物，更具体地，或其药学上可接受的盐或盐的溶剂合物，并且可用于治疗癌症。
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公开(公告)号：US20110144126A1
公开(公告)日：2011-06-16
申请号：US12634725
申请日：2009-12-10
IPC分类号： A61K31/4965 , C07D403/12 , A61P35/04
CPC分类号： C07D403/12 , A61K31/4965 , A61K45/06 , A61K2300/00
摘要： The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
摘要翻译： 本发明提供抑制Chk1的氨基吡唑化合物或其药学上可接受的盐或盐的溶剂化物，并且可用于治疗癌症。
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