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公开(公告)号：US20100190766A1
公开(公告)日：2010-07-29
申请号：US12635551
申请日：2009-12-10
Applicant: Heinz E. Moser , Qing Lu , Phillip A. Patten , Dan Wang , Ramesh Kasar , Stephen Kaldor , Brian D. Patterson
Inventor： Heinz E. Moser , Qing Lu , Phillip A. Patten , Dan Wang , Ramesh Kasar , Stephen Kaldor , Brian D. Patterson
IPC: A61K31/165 , C07C259/06 , C07D207/16 , A61K31/40 , C07C233/78 , A61K31/166 , C07D295/155 , A61K31/5375 , C07D213/61 , A61K31/44 , C07D413/10 , A61K31/5377 , C07D417/10 , C07D233/64 , A61K31/4164 , A61K31/4406 , C07D333/24 , A61K31/381 , A61K31/54 , C07D471/04 , A61K31/437 , C07D267/10 , A61K31/553 , C07C279/14 , A61K31/155 , A61P31/04
CPC classification number: C07D471/04 , C07C259/06 , C07C311/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/16 , C07D207/32 , C07D207/337 , C07D207/34 , C07D207/46 , C07D207/48 , C07D209/46 , C07D211/08 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/94 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/61 , C07D213/74 , C07D217/22 , C07D217/24 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/26 , C07D233/36 , C07D233/64 , C07D239/26 , C07D239/42 , C07D239/70 , C07D239/88 , C07D239/90 , C07D241/08 , C07D241/12 , C07D241/52 , C07D249/08 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/34 , C07D263/58 , C07D267/10 , C07D271/107 , C07D275/02 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/82 , C07D285/12 , C07D295/092 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/26 , C07D307/14 , C07D309/04 , C07D309/08 , C07D309/12 , C07D333/06 , C07D333/24 , C07D333/34 , C07D333/36 , C07D335/02 , C07D413/04
Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
Abstract translation: 提供式（I）的抗菌化合物：及其立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及这些化合物的制备方法。
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公开(公告)号：US20060293332A1
公开(公告)日：2006-12-28
申请号：US11429656
申请日：2006-05-05
Applicant: Francine Grant , Sarah Bartulis , Louis Brogley , Michael Dappen , Ramesh Kasar , Mohammed Khan , Martin Neitzel , Michael Pleiss , Eugene Thorsett , John Tucker , Michael Ye , Jon Hawkinson
Inventor： Francine Grant , Sarah Bartulis , Louis Brogley , Michael Dappen , Ramesh Kasar , Mohammed Khan , Martin Neitzel , Michael Pleiss , Eugene Thorsett , John Tucker , Michael Ye , Jon Hawkinson
IPC: A61K31/498 , C07D241/36
CPC classification number: C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
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3.发明授权5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts 有权5-（5-（2-（3-氨基丙氧基）-6-甲氧基苯基）-1H-吡唑-3-基氨基）吡嗪-2-甲腈，其药学上可接受的盐，或盐的溶剂合物公开(公告)号：US08314108B2
公开(公告)日：2012-11-20
申请号：US12634725
申请日：2009-12-10
Applicant: Francine S. Farouz , Ryan Coatsworth Holcomb , Ramesh Kasar , Steven Scott Myers
Inventor： Francine S. Farouz , Ryan Coatsworth Holcomb , Ramesh Kasar , Steven Scott Myers
IPC: A61K31/4965
CPC classification number: C07D403/12 , A61K31/4965 , A61K45/06 , A61K2300/00
Abstract: The present invention provides an aminopyrazole compound, more particularly, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
Abstract translation: 本发明提供抑制Chk1的氨基吡唑化合物，更具体地，或其药学上可接受的盐或盐的溶剂合物，并且可用于治疗癌症。
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公开(公告)号：US20110144126A1
公开(公告)日：2011-06-16
申请号：US12634725
申请日：2009-12-10
Applicant: Francine S. Farouz , Ryan Coatsworth Holcomb , Ramesh Kasar , Steven Scott Myers
Inventor： Francine S. Farouz , Ryan Coatsworth Holcomb , Ramesh Kasar , Steven Scott Myers
IPC: A61K31/4965 , C07D403/12 , A61P35/04
CPC classification number: C07D403/12 , A61K31/4965 , A61K45/06 , A61K2300/00
Abstract: The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
Abstract translation: 本发明提供抑制Chk1的氨基吡唑化合物或其药学上可接受的盐或盐的溶剂化物，并且可用于治疗癌症。
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Patent Agency Ranking
5.发明授权Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists 失效磺酰喹诺酮衍生物和相关化合物作为缓激肽拮抗剂公开(公告)号：US07635775B2
公开(公告)日：2009-12-22
申请号：US11429656
申请日：2006-05-05
Applicant: Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
Inventor： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
IPC: A61K31/498 , C07D241/50 , A61P11/06 , A61P25/06 , A61P25/02
CPC classification number: C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
Abstract translation: 公开了用作缓激肽拮抗剂的磺酰基喹喔啉乙酰胺衍生物。
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6.发明申请Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives 审中-公开芳基苯基氨基 - ，芳基苯基酰胺 - 和芳基苯基醚 - 硫化物衍生物公开(公告)号：US20070259863A1
公开(公告)日：2007-11-08
申请号：US11587732
申请日：2005-04-28
Applicant: Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
Inventor： Donovan Chin , Thomas Durand-Reville , Francine Farouz , Kerry Fowler , Kevin Guckian , Irina Jaconbson , Ramesh Kasar , Russell Petter , Daniel Scott , C. Gregory Sowell , Eugene Thorsett , Edward Yin-Shiang Lin
IPC: C07D307/54
CPC classification number: C07D233/64 , C07C323/62 , C07C2601/14 , C07C2602/44 , C07D207/14 , C07D207/26 , C07D211/56 , C07D211/58 , C07D213/34 , C07D213/56 , C07D231/40 , C07D257/04 , C07D261/08 , C07D261/10 , C07D295/185 , C07D307/54 , C07D309/14 , C07D333/34 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D451/02 , C07D451/04
Abstract: The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
Abstract translation: 本发明部分地涉及式I和III的化合物及其药学上可接受的盐和前药。 这些化合物可用于治疗疾病如炎症和免疫疾病。 本发明还涉及包含这些化合物的药物组合物，以及抑制受试者的炎症或抑制免疫应答的方法。
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公开(公告)号：US20070093485A1
公开(公告)日：2007-04-26
申请号：US10527384
申请日：2003-12-18
Applicant: Francine Farouz , Michael Dappen , Ying-Zi Xu , Sarah Bartulis , Ryan Holcomb , Ramesh Kasar , Michael Pleiss , Eugene Thorsett , Xiaocong Ye , Andrei Konradi
Inventor： Francine Farouz , Michael Dappen , Ying-Zi Xu , Sarah Bartulis , Ryan Holcomb , Ramesh Kasar , Michael Pleiss , Eugene Thorsett , Xiaocong Ye , Andrei Konradi
IPC: A61K31/5377 , A61K31/497 , A61K31/4965 , A61K31/496 , A61K31/4545 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/22 , C07D417/02 , C07D403/02
CPC classification number: C07D213/40 , C07C311/21 , C07D207/337 , C07D211/26 , C07D211/34 , C07D213/56 , C07D213/74 , C07D239/26 , C07D243/24 , C07D295/13 , C07D295/185 , C07D401/04 , C07D471/04
Abstract: Disclosed are certain substituted N-phenylsulfonamide derivatives and related compounds. These compounds are useful as bradykinin antagonists to relieve adverse symptoms in mammals mediated, at least in part, by bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.
Abstract translation: 公开了某些取代的N-苯基磺酰胺衍生物和相关化合物。 这些化合物可用作缓激肽拮抗剂，以缓解哺乳动物的不良反应，至少部分由缓激肽介导，包括疼痛，炎症，支气管收缩，脑水肿等。
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8.发明授权Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists 失效磺酰喹诺酮衍生物和相关化合物作为缓激肽拮抗剂公开(公告)号：US07183281B2
公开(公告)日：2007-02-27
申请号：US10429917
申请日：2003-05-02
Applicant: Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
Inventor： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Mohammed A. Khan , Martin Neitzel , Michael A. Pleiss , Eugene D. Thorsett , John Tucker , Michael Ye , Jon E. Hawkinson
IPC: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D413/00
CPC classification number: C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Disclosed are sulfonylquinoxalone derivatives of the general formula: These compounds are useful as bradykinin antagonists.
Abstract translation: 公开了以下通式的磺酰基喹诺酮衍生物：这些化合物可用作缓激肽拮抗剂。
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公开(公告)号：US07056937B2
公开(公告)日：2006-06-06
申请号：US10429203
申请日：2003-05-02
Applicant: Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Ryan Holcomb , Michael A. Pleiss , Eugene D. Thorsett , Michael Ye , Jon E. Hawkinson
Inventor： Francine S. Grant , Sarah Bartulis , Louis Brogley , Michael S. Dappen , Ramesh Kasar , Ryan Holcomb , Michael A. Pleiss , Eugene D. Thorsett , Michael Ye , Jon E. Hawkinson
IPC: A01N43/40 , A61K31/44 , C07D239/00 , C07D239/70 , C07D47/00
CPC classification number: C07D401/14 , C07D241/44 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Disclosed are 1-sulfonylquioxalone acetamides and derivatives thereof. The compounds are exemplified by compounds of the formula: Such compounds, derivatives and related compounds are useful as bradykinin antagonists.
Abstract translation: 公开了1-磺酰基二氧杂环己烷乙酰胺及其衍生物。 化合物的实例是下式的化合物：这样的化合物，衍生物和相关化合物可用作缓激肽拮抗剂。
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