公开(公告)号：US06604698B2

公开(公告)日：2003-08-12

申请号：US09852054

申请日：2001-05-10

申请人： Frank H. Verhoff ,  Robert A. Snow ,  Gary W. Pace

发明人： Frank H. Verhoff ,  Robert A. Snow ,  Gary W. Pace

IPC分类号： B02C1716

CPC分类号： A61K9/14 ,  A61K9/145 ,  B02C17/161 ,  Y10S977/775 ,  Y10S977/797 ,  Y10S977/90

摘要： This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a size distribution S2 which are smaller than S0; the very small milled substrate particles have a size distribution S3 and are smaller than all of the small media; and the large size media and the small size media are essentially retained in the milling chamber.