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141 条记录 (耗时 0.043 秒)

    Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
    4.
    发明授权
    Purine derivatives, the preparation thereof and their use as pharmaceutical compositions 有权
    嘌呤衍生物，其制备及其作为药物组合物的用途

    公开(公告)号：US07569574B2

    公开(公告)日：2009-08-04

    申请号：US10634047

    申请日：2003-08-04

    申请人： Roland Maier ,  Frank Himmelsbach ,  Matthias Eckhardt ,  Elke Langkopf ,  Michael Mark ,  Ralf R. H. Lotz

    发明人： Roland Maier ,  Frank Himmelsbach ,  Matthias Eckhardt ,  Elke Langkopf ,  Michael Mark ,  Ralf R. H. Lotz

    IPC分类号： C07D473/30 ,  C07D473/18 ,  C07D473/04 ,  C07D473/06 ,  A61K31/522 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D473/30

    摘要： The invention relates to new purine derivatives of general formula wherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.

    摘要翻译： 本发明涉及通式的新嘌呤衍生物，其中R 1至R 4如权利要求中所定义，互变异构体，立体异构体，混合物，其前药及其盐，特别是其与无机或有机酸的生理学上可接受的盐或 具有有价值的药理学性质的碱基，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用，其制备方法，其用于预防或治疗与增加的DPP-IV活性有关的疾病或病症的用途 或能够通过减少DPP-IV活性（特别是I型或II型糖尿病）来预防或缓解含有通式（I）化合物或其生理学上可接受的盐的药物组合物及其制备方法 。