公开(公告)号：US07851163B2

公开(公告)日：2010-12-14

申请号：US10168185

申请日：2000-12-18

申请人： Franz Paul Armbruster ,  Albert Missbichler ,  Heinrich Schmidt-Gayk ,  Heinz-Jürgen Roth

发明人： Franz Paul Armbruster ,  Albert Missbichler ,  Heinrich Schmidt-Gayk ,  Heinz-Jürgen Roth

IPC分类号： G01N33/53

CPC分类号： G01N33/78 ,  G01N2333/635

摘要： Immunoassay for the determination of parathyroid hormone activity in a sample, and for the diagnosis, etiology and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure 15 to 22 of the parathyroid hormone, and an antibody which recognizes whether the amino-terminal end 1 to 3 of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.

摘要翻译： 用于测定样品中甲状旁腺激素活性的免疫测定，以及钙代谢紊乱，骨病和超或甲状旁腺功能亢进症的诊断，病因和治疗。 借助于与甲状旁腺激素的受体结合结构15至22的区域中的表位结合的抗体和识别甲状旁腺的氨基末端1至3的抗体来测量甲状旁腺激素活性 激素是完整的。 该测定允许考虑一些甲状旁腺激素片段的拮抗特征。