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公开(公告)号:US20060193832A1
公开(公告)日:2006-08-31
申请号:US11345600
申请日:2006-02-01
申请人: Frederick Domann , Andrew Gaut , Douglas Trask , Gang Niu , Kimberly Krager
发明人: Frederick Domann , Andrew Gaut , Douglas Trask , Gang Niu , Kimberly Krager
CPC分类号: A61K48/00 , A61K38/177 , A61K51/02 , C12N15/86 , C12N2710/10343
摘要: The present invention relates to the use of gene therapy to introduce an iodine symporter into cell to increase iodine uptake therein. This approach has particular utility in the treatment of cancers that incapable of removing iodine. In addition, strategies are provided for reducing the export of sodium from cells to improve the efficacy of the iodine symporter gene therapy.
摘要翻译: 本发明涉及使用基因治疗将碘转运体引入细胞以增加碘摄入。 这种方法在治疗不能除去碘的癌症中具有特殊的用途。 此外,还提供了减少钠从细胞出口提高碘转运子基因治疗功效的策略。