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公开(公告)号：US08246967B2
公开(公告)日：2012-08-21
申请号：US11496837
申请日：2006-08-01
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译： 提供了修改一个或多个生物靶标的组合物和方法。 合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。 组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。 组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。 氧化还原活性配体有助于保持多于一个钌原子的分离。 合适的组合物还可以包括包含杂环芳族化合物的末端配体。 当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。 合适的组合物通常在还原剂存在下是催化和再生的。
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公开(公告)号：US08877215B2
公开(公告)日：2014-11-04
申请号：US13564169
申请日：2012-08-01
IPC分类号： A61K9/00 , C07F15/00 , A61F2/00 , A61K31/435
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译： 提供了修改一个或多个生物靶标的组合物和方法。 合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。 组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。 组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。 氧化还原活性配体有助于保持多于一个钌原子的分离。 合适的组合物还可以包括包含杂环芳族化合物的末端配体。 当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。 合适的组合物通常在还原剂存在下是催化和再生的。
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公开(公告)号：US20120295880A1
公开(公告)日：2012-11-22
申请号：US13564169
申请日：2012-08-01
IPC分类号： C07F15/00 , C12N9/99 , C12N5/09 , A61K31/555 , C12N5/071
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译： 提供了修改一个或多个生物靶标的组合物和方法。 合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。 组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。 组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。 氧化还原活性配体有助于保持多于一个钌原子的分离。 合适的组合物还可以包括包含杂环芳族化合物的末端配体。 当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。 合适的组合物通常在还原剂存在下是催化和再生的。
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