公开(公告)号：US20210403449A1

公开(公告)日：2021-12-30

申请号：US17468447

申请日：2021-09-07

Applicant: Fudan University

Inventor： Fener CHEN ,  Chunlin ZHUANG ,  Li DING

IPC: C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/14 ,  C07D239/48 ,  A61P31/18

Abstract: This application provides a biphenyl diaryl pyrimidine derivative with an aromatic heterocyclic structure, a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, where the biphenyl diaryl pyrimidine derivative is shown in formula (I). This application also provides a pharmaceutical composition containing the biphenyl diaryl pyrimidine derivative, or a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, and a pharmaceutically-acceptable carrier. This application further provides a method of treating AIDS by administering a therapeutically effective amount of the pharmaceutical composition to a patient in need.

公开(公告)号：US20210040109A1

公开(公告)日：2021-02-11

申请号：US16986200

申请日：2020-08-05

Applicant: Fudan University

Inventor： Fener CHEN ,  Yali SANG ,  Chunlin ZHUANG

IPC: C07D495/04 ,  A61P31/18

Abstract: A biphenyl-containing diarylpyrimido compound of formula (I), which is prepared by reacting a 4-chloropyrimidine derivative with a biphenyl derivative in a solvent in the presence of a base. A pharmaceutically-acceptable salt of the compound (I) and a pharmaceutical composition containing the compound (I) or a pharmaceutically-acceptable salt thereof are also provided.