公开(公告)号：US20250163084A1

公开(公告)日：2025-05-22

申请号：US19031731

申请日：2025-01-18

Applicant: Jiangxi Normal University ,  Fudan University

Inventor： Fener CHEN ,  Xianjing ZHENG ,  Chang LIU ,  Yiqun TIAN ,  Yajiao ZHANG ,  Li WAN ,  Chunxue PENG ,  Songlin ZHENG ,  Liangchuan LAI

IPC: C07F9/50 ,  B01J19/00 ,  C07F9/46

Abstract: A method of preparing an alkyl phosphate compound based on a micro-reaction system. The micro-reaction system includes a feed pump, a first micro-mixer, a second micro-mixer, a first micro-channel reactor, a second micro-channel reactor and a back-pressure device, where the first micro-mixer, the second micro-mixer, the first micro-channel reactor, the second micro-channel reactor and the back-pressure device are sequentially connected. The method includes the following steps. An alkylamine compound and an acid-binding agent are simultaneously fed to a first micro-mixer for mixing and then to the first micro-channel reactor for pre-reaction to obtain a pre-reaction solution. The pre-reaction solution and a phosphate or phosphite are simultaneously fed to the second micro-mixer for mixing to obtain a first reaction mixture. The first reaction mixture is fed to the second micro-channel reactor to carry out a condensation reaction under a back pressure condition and is concentrated to obtain the final product.

公开(公告)号：US20220281840A1

公开(公告)日：2022-09-08

申请号：US17740275

申请日：2022-05-09

Applicant: Fudan University

Inventor： Fener CHEN ,  Liangchuan LAI ,  Baijun YE ,  Meifen JIANG

IPC: C07D401/12 ,  B01J4/00 ,  B01J8/02

Abstract: Disclosed is a method of continuously preparing N,N-Bis(2,2,6,6-tetramethyl-4-piperidyl)-1,6-hexamethylenediamine, which relates to chemical engineering. The Pt/C catalyst and the quartz sand are mixed uniformly and loaded to the continuous-flow fixed-bed reactor. Then, hydrogen gas and a substrate solution containing 2,2,6,6-tetramethyl-4-piperidinone and 1,6-hexanediamine are simultaneously fed to the micro-mixer and the continuous-flow fixed-bed reactor in sequence to undergo a continuous catalytic reductive amination to obtain the N,N-Bis(2,2,6,6-tetramethyl-4-piperidyl)-1,6-hexamethylenediamine.