公开(公告)号：US20230234937A1

公开(公告)日：2023-07-27

申请号：US18010474

申请日：2021-06-15

申请人： Merck Patent GmbH

发明人： Jens ENGELHART ,  Margarita WUCHERER-PLIETKER ,  Sebastian MEYER ,  Christian EICKHOFF

IPC分类号： C07D401/10 ,  C07D471/04 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D221/20 ,  C07D491/107 ,  C07F9/46 ,  H10K50/15 ,  H10K50/165 ,  H10K85/60

CPC分类号： C07D401/10 ,  C07D471/04 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D221/20 ,  C07D491/107 ,  C07F9/46 ,  H10K50/15 ,  H10K50/165 ,  H10K85/6572

摘要： The present invention relates indenoazanaphthalenes, particularly for use in electronic devices. The invention further relates to a method for producing the indenoazanaphthalenes according to the invention, and to electronic devices comprising the same.

公开(公告)号：US10414699B2

公开(公告)日：2019-09-17

申请号：US15166991

申请日：2016-05-27

申请人： Chevron Phillips Chemical Company LP

发明人： Steven M. Bischof ,  Orson L. Sydora ,  Jared T. Fern ,  Uriah J. Kilgore ,  Steven Ross Hutchison ,  Ray Rios ,  Eric R. Fernandez

IPC分类号： C07C2/36 ,  B01J31/24 ,  C07F9/46 ,  C07F9/6561 ,  C07F11/00 ,  C08F4/69

摘要： Disclosed are processes, systems, and reaction systems for the oligomerization of ethylene to form an oligomer product in a reaction zone using a catalyst system having i) a chromium component comprising an N2-phosphinyl amidine chromium compound complex, an N2-phosphinyl formamidine chromium compound complex, an N2-phosphinyl guanidine chromium compound complex, or any combination thereof, and ii) an aluminoxane. Ethylene can be contacted with an organic reaction medium to form an ethylene feedstock mixture prior to contact with the catalyst system. The ethylene feedstock mixture can be contacted with the catalyst system inside or outside of the reaction zone.

公开(公告)号：US09850233B2

公开(公告)日：2017-12-26

申请号：US15207915

申请日：2016-07-12

申请人： Respivert Limited ,  Topivert Pharma Limited

发明人： Matthew Colin Thor Fyfe

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/675 ,  A61K45/06 ,  C07F9/46

CPC分类号： C07D403/12 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07F9/46

摘要： There are provided compounds of formula I, wherein: Y represents NR2R3; one of R2 and R3 represents —[C2-4 alkylene-O]1-12—[C2-4 alkylene]-R2a and the other of R2 and R3 has a meaning given in the description; and R, R1, R2a, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

公开(公告)号：US20170313634A1

公开(公告)日：2017-11-02

申请号：US15101559

申请日：2014-11-28

申请人： NOVA Chemicals (International) S.A.

发明人： Stephen Brown ,  Charles Carter ,  Peter Zoricak ,  Xiaoliang Gao ,  Holly Ann Severin

IPC分类号： C07C2/32 ,  C07F9/46 ,  B01J31/14 ,  B01J31/18

CPC分类号： C07C2/32 ,  B01J31/143 ,  B01J31/1875 ,  B01J31/188 ,  B01J2231/20 ,  B01J2531/62 ,  C07C2/34 ,  C07C2531/14 ,  C07C2531/22 ,  C07C2531/24 ,  C07C2531/34 ,  C07F9/46 ,  C08F2410/04 ,  Y02P20/52 ,  C07C11/02 ,  C08F10/00 ,  C08F4/69267

摘要： The selective oligomerization of ethylene to produce a mixture comprising octene and hexene is conducted in the presence of a catalyst system comprising a source of chromium; two different P—N—P ligands and an activator. The phosphorus atoms of both ligands have ortho-fluoro phenyl substituents. The nitrogen atom of the first ligand has an isopropyl substituent. The nitrogen of the second ligand has a larger/bulkier hydrocarbyl substituent on the N atom. The hexene produced by the process of this invention has very high alpha selectivity.

公开(公告)号：US20170305945A1

公开(公告)日：2017-10-26

申请号：US15649077

申请日：2017-07-13

申请人： Chevron Phillips Chemical Company LP

发明人： Orson L. Sydora ,  Michael Carney ,  Brooke L. Small ,  Steven Hutchison

IPC分类号： C07F11/00 ,  C08F10/00 ,  B01J31/18 ,  B01J31/22 ,  C07F9/50 ,  C07F9/6533 ,  C07F9/6539 ,  C07F19/00 ,  C08F4/78 ,  C07F9/46 ,  C07F9/28 ,  C07D265/30 ,  C07D233/54 ,  B01J31/14 ,  C08G61/04 ,  C07C2/36 ,  C07C2/32 ,  C08F110/02 ,  C08F210/16

CPC分类号： C07F11/005 ,  B01J31/143 ,  B01J31/18 ,  B01J31/188 ,  B01J31/189 ,  B01J31/2295 ,  B01J2231/20 ,  B01J2531/62 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2/32 ,  C07C2/36 ,  C07C2531/14 ,  C07C2531/24 ,  C07D233/54 ,  C07D265/30 ,  C07F9/28 ,  C07F9/46 ,  C07F9/5004 ,  C07F9/5022 ,  C07F9/6533 ,  C07F9/6539 ,  C07F11/00 ,  C07F19/005 ,  C08F4/78 ,  C08F10/00 ,  C08F110/02 ,  C08F210/16 ,  C08G61/04 ,  C08F4/69068 ,  C08F210/14

摘要： N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

公开(公告)号：US09637508B2

公开(公告)日：2017-05-02

申请号：US14894132

申请日：2014-11-18

申请人： LG CHEM, LTD.

发明人： Yong Ho Lee ,  Eun Ji Shin ,  Seok Pil Sa ,  Ki Soo Lee

IPC分类号： C07F9/46 ,  C07C2/36 ,  C07C211/54 ,  C08F4/00 ,  B01J31/14 ,  B01J31/18 ,  C07C2/32 ,  C07C11/107 ,  C08F110/02

CPC分类号： C07F9/46 ,  B01J31/143 ,  B01J31/188 ,  B01J2231/20 ,  B01J2531/0258 ,  B01J2531/62 ,  C07C2/32 ,  C07C2/36 ,  C07C211/54 ,  C07C2531/14 ,  C07C2531/22 ,  C08F4/00 ,  C07C11/107 ,  C08F110/02 ,  C08F2500/02 ,  C08F4/69267

摘要： Provided are ligand compounds containing two or more diphosphinoamine functional groups, where the two or more diphosphinoamine functional groups are linked by 4 carbon atoms, a catalyst system including the ligand compounds for olefin oligomerization, and a method for olefin oligomerization using the same. The catalyst system for olefin oligomerization according to the present invention has excellent catalytic activity, and yet, exhibits high selectivity to 1-hexene and 1-octene, thus enabling efficient preparation of alpha-olefin.

公开(公告)号：US20150025042A1

公开(公告)日：2015-01-22

申请号：US14108162

申请日：2013-12-16

申请人： Shoujun Chen ,  Keizo Koya ,  Zachary Demko ,  Lijun Sun

发明人： Shoujun Chen ,  Keizo Koya ,  Zachary Demko ,  Lijun Sun

IPC分类号： C07C327/56 ,  A61K31/16 ,  C07C257/22 ,  A61K31/277 ,  C07C311/55 ,  A61K31/18 ,  C07C243/34 ,  C07F9/22 ,  A61K31/664 ,  C07F9/46 ,  C07D307/66 ,  A61K31/341 ,  C07D207/34 ,  A61K31/40 ,  C07D271/113 ,  A61K31/4245 ,  A61K31/166

CPC分类号： C07C327/56 ,  A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/40 ,  A61K31/4245 ,  A61K31/664 ,  C07C243/28 ,  C07C243/34 ,  C07C255/66 ,  C07C257/22 ,  C07C261/04 ,  C07C281/06 ,  C07C307/04 ,  C07C311/49 ,  C07C311/51 ,  C07C311/55 ,  C07C337/06 ,  C07C2601/02 ,  C07D207/34 ,  C07D207/36 ,  C07D233/74 ,  C07D263/48 ,  C07D271/10 ,  C07D271/113 ,  C07D307/66 ,  C07F9/228 ,  C07F9/4423 ,  C07F9/4496 ,  C07F9/46

摘要： Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.

摘要翻译： 公开了式（I），（III），（IV），（VII），（X），（XI），（XII），（XIII）和（XIV）的化合物，其中变量如权利要求 以及使用本发明化合物治疗患有增殖性疾病（例如癌症）的受试者的方法，以及用于治疗对Hsp70诱导和/或自然杀伤诱导反应的病症的方法。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物。

公开(公告)号：US08461371B2

公开(公告)日：2013-06-11

申请号：US12899092

申请日：2010-10-06

申请人： Biing-Jiun Uang ,  Wei-Ming Huang

发明人： Biing-Jiun Uang ,  Wei-Ming Huang

IPC分类号： C07F9/36 ,  C07F9/46 ,  A01N47/34 ,  C07C337/00 ,  C07C211/00 ,  C07C17/42 ,  C09B11/02

CPC分类号： C07F9/36

摘要： The present invention relates to a method of enantioselective addition to imines, including: reacting R3CH═NY with R4ZnR5 in the presence of a compound represented by the following formula (I), in which Y, R1, R2, R3, R4 and R5 are defined the same as the specification. Accordingly, the present invention can prepare secondary amines in high yields and enantiomeric excess by the above-mentioned method.

摘要翻译： 本发明涉及一种对映选择性加成亚胺的方法，包括：在下列通式（I）表示的化合物存在下，使R3CH = NY与R4ZnR5反应，其中Y，R1，R2，R3，R4和R5为 定义与规范相同。 因此，本发明可以通过上述方法以高收率和对映体过量制备仲胺。

公开(公告)号：US20050288523A1

公开(公告)日：2005-12-29

申请号：US11125374

申请日：2005-05-09

申请人： Paul Knochel ,  Tanasari Bunlaksananusorn ,  Andrei Gavryushin

发明人： Paul Knochel ,  Tanasari Bunlaksananusorn ,  Andrei Gavryushin

IPC分类号： B01J31/24 ,  C07B35/02 ,  C07B53/00 ,  C07B61/00 ,  C07C29/03 ,  C07C33/02 ,  C07C35/06 ,  C07C45/50 ,  C07C45/69 ,  C07C49/67 ,  C07C67/343 ,  C07C69/38 ,  C07C69/732 ,  C07C233/47 ,  C07C243/38 ,  C07F5/02 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F15/00 ,  C07F9/02

CPC分类号： C07F9/5027 ,  B01J31/2414 ,  B01J2231/341 ,  B01J2231/44 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  C07B2200/07 ,  C07F9/5018 ,  C07F9/532

摘要： The present invention relates to chiral diphosphorus compounds and transition metal complexes thereof, to a process for preparing chiral diphosphorus compounds and oxides thereof, and transition metal complexes comprising the chiral diphosphorus compounds. In a further aspect, the invention relates to the use of the chiral diphosphorus compounds or transition metal complexes thereof in asymmetric syntheses.

摘要翻译： 本发明涉及手性二磷化合物及其过渡金属络合物，涉及制备手性二磷化合物及其氧化物的方法，以及包含手性二磷化合物的过渡金属络合物。 另一方面，本发明涉及手性二磷化合物或其过渡金属络合物在不对称合成中的用途。

公开(公告)号：US06977312B2

公开(公告)日：2005-12-20

申请号：US10203296

申请日：2001-02-09

申请人： Wolfgang Ahlers ,  Michael Röper ,  Peter Hofmann ,  Daniel C. M. Warth ,  Rocco Paciello

发明人： Wolfgang Ahlers ,  Michael Röper ,  Peter Hofmann ,  Daniel C. M. Warth ,  Rocco Paciello

IPC分类号： B01J31/16 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07B37/12 ,  C07C2/50 ,  C07C13/44 ,  C07C13/64 ,  C07C13/68 ,  C07C45/50 ,  C07C51/14 ,  C07C253/10 ,  C07F9/46 ,  C07F9/50 ,  C07F9/6561 ,  C07F9/6571 ,  C07F9/6574 ,  C07F15/00 ,  C07F15/04 ,  C07F15/06 ,  C08F4/42 ,  C07F9/02

CPC分类号： C07F9/65746 ,  B01J31/1658 ,  B01J31/185 ,  B01J31/1865 ,  B01J31/1875 ,  B01J31/2457 ,  B01J2231/12 ,  B01J2231/20 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/543 ,  B01J2231/645 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/845 ,  B01J2531/847 ,  C07C45/50 ,  C07C253/10 ,  C07F9/46 ,  C07F9/5027 ,  C07F9/6561 ,  C07F9/65719 ,  C07C47/02 ,  C07C255/04

摘要： Novel compounds of phosphorus, of arsenic and of antimony can be used as ligands to form complexes of metals of transition group VIII which can be used in catalysts for hydroformylation, hydrocyanation, carbonylation, hydrogenations, oligomerization and polymerization of olefins and for metathesis.

摘要翻译： 可以使用磷，砷和锑的新型化合物作为配体，形成可用于加氢甲酰化，氢化氰化，羰基化，氢化，烯烃低聚和聚合的复合催化剂的过渡基团VIII的金属络合物和复分解。