公开(公告)号：US20110009352A1

公开(公告)日：2011-01-13

申请号：US12831559

申请日：2010-07-07

申请人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Tsuyoshi Yoshida ,  Shohei Yoshida

发明人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Tsuyoshi Yoshida ,  Shohei Yoshida

IPC分类号： A61K31/704 ,  C07H15/256 ,  A61P43/00

CPC分类号： A61K31/704 ,  A61K2300/00

摘要： There is provided a medicament capable of enhancing the antimicrobial peptide production ability. The medicament contains, as an active ingredient, a compound which is glycyrrhizin or a pharmaceutically acceptable salt thereof and capable of inhibiting the production of at least one of interleukin-10 (IL-10) and chemokine CCL2. The antimicrobial peptide is preferably defensin or cathelicidin.

摘要翻译： 提供能够增强抗微生物肽生产能力的药物。 作为活性成分，作为活性成分，含有甘草甜素或其药学上可接受的盐，能够抑制白细胞介素-10（IL-10）和趋化因子CCL2中的至少一种的生成的化合物作为活性成分。 抗微生物肽优选为防御素或导管素。

公开(公告)号：US20060116337A1

公开(公告)日：2006-06-01

申请号：US11265328

申请日：2005-11-01

申请人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

发明人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

IPC分类号： A61K31/704 ,  A61K31/235

CPC分类号： A61K31/473 ,  A61K31/57 ,  A61K31/704 ,  A61K31/7052

摘要： The object of the present invention is to provide the use of glycyrrhizin and its derivatives for inhibition of MCP-1 production. The present invention discloses an MCP-1 production inhibition method and pharmaceutical composition for the same comprising administration of glycyrrhizin and its derivatives in an amount effective for said inhibition to mammals in which migration of monocytes or T lymphocytes is increased, or production of IL-10 is increased, and inhibition of said increase is desired, thereby treating or preventing decreases in infection resistance.

摘要翻译： 本发明的目的是提供甘草甜素及其衍生物用于抑制MCP-1产生的用途。 本发明公开了一种MCP-1产生抑制方法及其药物组合物，其含有对所述抑制单核细胞或T淋巴细胞迁移的哺乳动物有效量的甘草甜素及其衍生物的给药量，或产生IL-10 并且希望抑制所述增加，从而治疗或防止耐感染性降低。

公开(公告)号：US07015202B2

公开(公告)日：2006-03-21

申请号：US10694616

申请日：2003-10-23

申请人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

发明人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

IPC分类号： A61K31/70 ,  A61K31/56

CPC分类号： A61K31/473 ,  A61K31/57 ,  A61K31/704 ,  A61K31/7052

摘要： The object of the present invention is to provide the use of glycyrrhizin and its derivatives for inhibition of MCP-1 production. The present invention discloses an MCP-1 production inhibition method and pharmaceutical composition for the same comprising administration of glycyrrhizin and its derivatives in an amount effective for said inhibition to mammals in which migration of monocytes or T lymphocytes is increased, or production of IL-10 is increased, and inhibition of said increase is desired.

摘要翻译： 本发明的目的是提供甘草甜素及其衍生物用于抑制MCP-1产生的用途。 本发明公开了一种MCP-1产生抑制方法及其药物组合物，其含有对所述抑制单核细胞或T淋巴细胞迁移的哺乳动物有效量的甘草甜素及其衍生物的给药量，或产生IL-10 增加，并且希望抑制所述增加。