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公开(公告)号：US20120244210A1
公开(公告)日：2012-09-27
申请号：US13437428
申请日：2012-04-02
申请人： Fumikazu SHINOHARA , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
发明人： Fumikazu SHINOHARA , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
IPC分类号： A61K9/127 , A61P35/00 , A61P29/00 , A61K31/713
CPC分类号： A61K9/0019 , A61K9/1271 , C12N15/1135 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a composition that comprises a lipidparticle encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the lipidparticle contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.
摘要翻译： 本发明提供了包含包封双链核酸分子的脂质粒子的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质颗粒含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。
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公开(公告)号：US20140039034A1
公开(公告)日：2014-02-06
申请号：US13980139
申请日：2011-02-02
申请人： Fumikazu Shinohara , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
发明人： Fumikazu Shinohara , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
IPC分类号： A61K47/44
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/713 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a composition that comprises a lipidparticle encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the lipidparticle contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.
摘要翻译： 本发明提供了包含包封双链核酸分子的脂质粒子的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质颗粒含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。
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公开(公告)号：US20120207818A1
公开(公告)日：2012-08-16
申请号：US13348959
申请日：2012-01-12
申请人： Fumikazu SHINOHARA , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
发明人： Fumikazu SHINOHARA , Tetsuo Yoshida , Hiroko Sugishita , Tomoyuki Naoi , Toshihiko Ishii , Junichi Enokizono
IPC分类号： A61K9/127 , A61P35/00 , A61P29/00 , A61K31/7088
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/10 , A61K9/1271 , C12N15/1135 , C12N2310/11 , C12N2320/32 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides a composition that comprises a liposome encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the liposome contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.
摘要翻译： 本发明提供一种包含包封双链核酸分子的脂质体的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质体含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。
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公开(公告)号：US09937127B2
公开(公告)日：2018-04-10
申请号：US11883169
申请日：2006-01-27
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/107 , B01J13/02
摘要： An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.
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5.发明申请Method of Producing Fine Particles Surface-Modified with Water-Soluble Substance 有权生产用水溶性物质表面改性的微粒的方法公开(公告)号：US20080145414A1
公开(公告)日：2008-06-19
申请号：US11883169
申请日：2006-01-27
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/107 , B01J13/02
摘要： An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.
摘要翻译： 本发明的目的是提供一种容易地生产包含脂质，脂肪酸或其衍生物的细颗粒的方法，其用水溶性物质表面改性等。提供了一种制备精细的方法 用水溶性物质进行表面改性的粒子，其含有分散包含脂质，脂肪酸或其衍生物的微粒子的工序，溶解或分散作为脂质衍生物的表面改性剂，脂肪酸衍生物 ，或水溶性物质的脂族烃衍生物，在含有极性有机溶剂的液体中等。
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