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    Imidazoquinolone derivatives
    2.
    发明授权
    Imidazoquinolone derivatives 失效
    咪唑喹啉酮衍生物

    公开(公告)号：US4994468A

    公开(公告)日：1991-02-19

    申请号：US489025

    申请日：1990-03-05

    申请人： Fumio Suzuki ,  Takeshi Kuroda ,  Yoshisuke Nakazato ,  Kenji Ohmori ,  Haruhiko Manabe

    发明人： Fumio Suzuki ,  Takeshi Kuroda ,  Yoshisuke Nakazato ,  Kenji Ohmori ,  Haruhiko Manabe

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Novel imidazoquinolone derivative represented by the formula (I); ##STR1## wherein R.sup.1 represents hydrogen, alkyl, cycloalkyl, alkenyl aralkyl, aralkenyl or substituted or unsubstituted aryl; X represents nitrogen or ##STR2## where R.sup.2 is hydrogen, hydroxyl, alkyl, cycloalkyl, alkenyl, aralkyl, aralkenyl, substituted or unsubstituted aryl, thiol, halogen, substituted or unsubstituted aromatic heterocyclic group, or --(CH.sub.2).sub.m CO.sub.2 R.sup.6 where R.sup.6 is hydrogen or lower alkyl and m is an integer of 0 to 3; Y represents oxygen or sulfur; R.sup.3 represents alkyl, cycloalkyl, alkoxyalkly, alkenyl, aralkyl, aralkenyl, --(CH.sub.2).sub.n -- Het where Het is substituted or unsubstituted aromatic heterocyclic group and n is an integer of 1 to 3 or --(CH.sub.2).sub.n CO.sub.2 R.sup.6a where n has the same meaning as defined above and R.sup.6a has the same meaning as defined as to R.sup.6 ; each of R.sup.4 and R.sup.5 independently represents hydrogen, lower alkyl, trifluoromethyl, cycloalkyl, halogen, hydroxyl, lower alkoxyl, lower alkylthio, nitro, amino, lower alkylamino, lower alkanoylamino, aroylamino, lower alkanoyl or aroyl; and a pharmaceutically acceptable salt thereof. The Compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.

    Imidazonaphthyridine derivatives
    3.
    发明授权
    Imidazonaphthyridine derivatives 失效
    咪唑并萘啶衍生物

    公开(公告)号：US5536730A

    公开(公告)日：1996-07-16

    申请号：US526323

    申请日：1995-09-11

    申请人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    发明人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    IPC分类号： A61K31/435 ,  A61K31/4375 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  C07D471/14 ,  A61K31/41

    CPC分类号： C07D471/14

    摘要： Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX-Y-Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C(R.sup.5)H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen, or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable salts thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

    摘要翻译： 公开了由式（I）表示的咪唑并吡啶衍生物其中：R1表示低级烷基或取代或未取代的芳基; 并且XYZ表示其中R2表示氢，低级烷基，烯基，芳烯基或-C（R5）H-（CH2）n-R4（其中R4表示取代或未取代的芳基，取代或未取代的吡啶基，取代或未取代的呋喃基 ，羟基取代的低级烷基，低级烷酰氧基，吗啉代，低级烷酰基，羧基，低级烷氧基羰基，环烷基，羟基，低级烷氧基，卤素或NR6R7，其中R6和R7独立代表氢或低级烷基; R5代表氢，低级烷基或 苯基; n表示0〜3的整数）; 并且R 3表示氢，巯基，羟基，低级烷基或芳基及其药学上可接受的盐。 这些化合物显示有效的抗炎，抗过敏和支气管扩张活性。

    Imidazonaphthyridine derivatives
    5.
    发明授权
    Imidazonaphthyridine derivatives 失效
    咪唑并萘啶衍生物

    公开(公告)号：US5468756A

    公开(公告)日：1995-11-21

    申请号：US241631

    申请日：1994-05-12

    申请人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    发明人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    IPC分类号： A61K31/435 ,  A61K31/4375 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  C07D471/14 ,  C07D471/00 ,  A61K31/44

    CPC分类号： C07D471/14

    摘要： Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX--Y--Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R.sup.5)H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryland pharmaceutically acceptable salts thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

    摘要翻译： 公开了由式（I）表示的咪唑并吡啶衍生物其中：R1表示低级烷基或取代或未取代的芳基; 并且XYZ表示其中R2表示氢，低级烷基，烯基，芳烯基或-C（R5）H-（CH2）n-R4（其中R4表示取代或未取代的芳基，取代或未取代的吡啶基，取代或未取代的呋喃基 羟基取代的低级烷基，低级烷酰氧基，吗啉代，低级烷酰基，羧基，低级烷氧基羰基，环烷基，羟基，低级烷氧基，卤素或NR6R7，其中R6和R7独立地表示氢或低级烷基; R5表示氢，低级烷基或苯基; n表示0〜3的整数）。 并且R 3表示氢，巯基，羟基，低级烷基或芳基及其药学上可接受的盐。 这些化合物显示有效的抗炎，抗过敏和支气管扩张活性。

    Imidazonaphthyridine derivatives
    9.
    发明授权
    Imidazonaphthyridine derivatives 失效
    咪唑并萘啶衍生物

    公开(公告)号：US5364859A

    公开(公告)日：1994-11-15

    申请号：US999658

    申请日：1992-12-29

    申请人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    发明人： Fumio Suzuki ,  Takeshi Kuroda ,  Shigeto Kitamura ,  Kenji Ohmori

    IPC分类号： A61K31/435 ,  A61K31/4375 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  C07D471/14 ,  C07D487/04 ,  A61K31/53

    CPC分类号： C07D471/14

    摘要： Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; andX-Y-Z represents ##STR2## wherein R.sup.2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R.sup.5) H--(CH.sub.2).sub.n --R.sup.4 (wherein R.sup.4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 independently represents hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R.sup.3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof.The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

    摘要翻译： 公开了由式（I）表示的咪唑并吡啶衍生物其中：R1表示低级烷基或取代或未取代的芳基; 并且XYZ表示其中R2表示氢，低级烷基，烯基，芳烯基或-C（R5）H-（CH2）n-R4（其中R4表示取代或未取代的芳基，取代或未取代的吡啶基，取代或未取代的呋喃基 ，羟基取代的低级烷基，低级烷酰氧基，吗啉代，低级烷酰基，羧基，低级烷氧基羰基，环烷基，羟基，低级烷氧基，卤素或NR6R7，其中R6和R7独立地表示氢或低级烷基; R5代表氢，低级烷基或苯基 ; n表示0〜3的整数）。 并且R 3表示氢，巯基，羟基，低级烷基或芳基及其药学上可接受的风帆。 这些化合物显示有效的抗炎，抗过敏和支气管扩张活性。