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公开(公告)号：US20160296528A1
公开(公告)日：2016-10-13
申请号：US15006755
申请日：2016-01-26
发明人： Joaquin Pastor Fernández , Rosa María Álvarez Escobar , Rosario Concepción Riesco Fagundo , Ana Belén García García , Antonio Rodríguez Hergueta , Jose Ignacio Martín Hernando , Carmen Blanco Aparicio , David Álvaro Cebrián Muñoz
IPC分类号： A61K31/5383 , A61K31/4375 , A61K31/519 , A61K31/5025 , A61K31/4745 , A61K31/439
CPC分类号： A61K31/5383 , A61K31/4375 , A61K31/439 , A61K31/4745 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D513/16 , C07D513/22 , C07D515/22 , A61K2300/00
摘要： There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
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公开(公告)号：US09808466B2
公开(公告)日：2017-11-07
申请号：US15006755
申请日：2016-01-26
发明人： Joaquín Pastor Fernández , Rosa María Álvarez Escobar , Rosario Concepción Riesco Fagundo , Ana Belén García García , Antonio Rodríguez Hergueta , Jose Ignacio Martín Hernando , Carmen Blanco Aparicio , David Álvaro Cebrián Muñoz
IPC分类号： A61K45/06 , A61K31/5383 , C07D513/16 , C07D513/22 , C07D515/22 , A61K31/4375 , A61K31/439 , A61K31/4745 , A61K31/5025 , A61K31/519
CPC分类号： A61K31/5383 , A61K31/4375 , A61K31/439 , A61K31/4745 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D513/16 , C07D513/22 , C07D515/22 , A61K2300/00
摘要： There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
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