公开(公告)号：US20220241484A1

公开(公告)日：2022-08-04

申请号：US17433761

申请日：2020-03-06

申请人： GAMBRO LUNDIA AB

发明人： Jan SWARTJES ,  Markus STORR ,  Martin REMPFER ,  Isabelle LITZINGER ,  Stefanie VOTTELER ,  Philipp KUHN

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M1/16 ,  B01D63/02 ,  B01D69/14 ,  B01D71/68 ,  B01D71/42

摘要： The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).