公开(公告)号：US20180036445A1

公开(公告)日：2018-02-08

申请号：US15554075

申请日：2016-02-25

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Elin Marianne Monie ,  Tomas Bjorkman ,  Anna Gronberg ,  Anders Ljunglof ,  Gustav Jose Rodrigo ,  Karin Torstenson ,  Magnus Carl Erik Wetterhall

IPC: A61L2/18 ,  B01D15/20 ,  B01D15/38 ,  G01N30/50

CPC classification number: A61L2/18 ,  B01D15/203 ,  B01D15/3804 ,  G01N30/50

Abstract: The invention discloses a method for cleaning or sanitization of an affinity chromatography matrix, comprising the steps of: a) providing an affinity chromatography matrix having oxidation-tolerant proteinaceous ligands coupled to a support, b) contacting the matrix with a sanitization solution comprising at least one oxidant defined by formula I, R—O—O—H (I) wherein R is hydrogen or an acyl group R′—C(O)—, with R′ being a hydrogen or a methyl, ethyl or propyl group.