公开(公告)号：US10941124B2

公开(公告)日：2021-03-09

申请号：US16062205

申请日：2016-12-19

申请人： GE Healthcare AS

发明人： Andreas Richard Meijer ,  Arne Wang Aabye ,  Khalid Hussain ,  Sondre Nilsen ,  Mikkel Jacob Thaning ,  Jarle Andre Haugan ,  Ingvil Gausemel ,  Nikolai Enes ,  Silalahi Sumihar

IPC分类号： C07D257/02 ,  B01D9/00

摘要： The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.

公开(公告)号：US20180370925A1

公开(公告)日：2018-12-27

申请号：US16062205

申请日：2016-12-19

申请人： GE Healthcare AS

发明人： Andreas Richard Meijer ,  Arne Wang Aabye ,  Khalid Hussain ,  Sondre Nilsen ,  Mikkel Jacob Thaning ,  Jarle Andre Haugan ,  Ingvil Gausemel ,  Nikolai Enes ,  Silalahi Sumihar

IPC分类号： C07D257/02 ,  B01D9/00

摘要： The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.