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公开(公告)号：US11534494B2
公开(公告)日：2022-12-27
申请号：US16997188
申请日：2020-08-19
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US09999692B2
公开(公告)日：2018-06-19
申请号：US14780900
申请日：2014-03-28
发明人： Torild Wickstrom
IPC分类号： A61K51/00 , A61K51/04 , C07B59/00 , C07C51/377 , C07C61/15
CPC分类号： A61K51/0402 , A61K51/0406 , A61K51/0497 , C07B59/001 , C07B2200/05 , C07C51/377 , C07C61/15 , C07C227/20 , C07C269/06 , C07C2601/04 , C07C271/24 , C07C229/48
摘要： The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
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公开(公告)号：US11077216B2
公开(公告)日：2021-08-03
申请号：US15318599
申请日：2015-06-30
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , C07B59/00 , C07C227/20
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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公开(公告)号：US20210030878A1
公开(公告)日：2021-02-04
申请号：US16997188
申请日：2020-08-19
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US20180177900A1
公开(公告)日：2018-06-28
申请号：US15900716
申请日：2018-02-20
发明人： Torild Wickstrom
IPC分类号： A61K51/04 , C07C61/15 , C07C51/377 , C07B59/00
CPC分类号： A61K51/0402 , A61K51/0406 , A61K51/0497 , C07B59/001 , C07B2200/05 , C07C51/377 , C07C61/15 , C07C227/20 , C07C269/06 , C07C2601/04 , C07C271/24 , C07C229/48
摘要： The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
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公开(公告)号：US20160051710A1
公开(公告)日：2016-02-25
申请号：US14780900
申请日：2014-03-28
发明人： Torild Wickstrom
IPC分类号： A61K51/04 , C07C61/15 , C07C51/377
CPC分类号： A61K51/0402 , A61K51/0406 , A61K51/0497 , C07B59/001 , C07B2200/05 , C07C51/377 , C07C61/15 , C07C227/20 , C07C269/06 , C07C2601/04 , C07C271/24 , C07C229/48
摘要： The present invention relates to a novel composition comprising 1-amino-3[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
摘要翻译： 本发明涉及包含1-氨基-3 [18 F] - 氟代环丁烷羧酸（[18 F] -FACBC））的新型组合物，其中所述组合物与包含[18 F] -FACBC的已知组合物相比具有一定的优异性能。 本发明还提供了获得所述组合物的方法。
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公开(公告)号：US20220001034A1
公开(公告)日：2022-01-06
申请号：US17366681
申请日：2021-07-02
IPC分类号： A61K51/04 , C07B59/00 , C07C227/20
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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公开(公告)号：US20170128597A1
公开(公告)日：2017-05-11
申请号：US15318599
申请日：2015-06-30
IPC分类号： A61K51/04 , C07B59/00 , C07C227/20
CPC分类号： A61K51/0402 , C07B59/001 , C07B2200/05 , C07C227/20 , C07C2601/04
摘要： The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.
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公开(公告)号：US20230068052A1
公开(公告)日：2023-03-02
申请号：US17962686
申请日：2022-10-10
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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公开(公告)号：US20220111052A1
公开(公告)日：2022-04-14
申请号：US17557755
申请日：2021-12-21
摘要： The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
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