公开(公告)号：US20160008427A1

公开(公告)日：2016-01-14

申请号：US14690891

申请日：2015-04-20

Applicant: GENENTECH, INC.

Inventor： Sachdev S. SIDHU ,  Bing LI ,  Menno VAN LOOKEREN CAMPAGNE ,  Christian WIESMANN

IPC: A61K38/17

CPC classification number: A61K38/1774 ,  A61K38/00 ,  C07K14/70503 ,  Y02A50/463

Abstract: The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.

Abstract translation: 本发明涉及亲和力成熟的CRIg变体。 特别地，本发明涉及具有增加的对C3b的结合亲和力并保留在C3上选择性结合C3b的CRIg变体。