公开(公告)号：US20170073405A1

公开(公告)日：2017-03-16

申请号：US15137577

申请日：2016-04-25

Applicant: Genentech, Inc.

Inventor： Germaine FUH ,  Hans-Peter GERBER ,  Wei-Ching LIANG ,  Frederic FELLOUSE ,  Sachdev S. SIDHU ,  Christian WIESMANN

IPC: C07K16/22 ,  C07K16/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。

公开(公告)号：US20150232549A1

公开(公告)日：2015-08-20

申请号：US14636782

申请日：2015-03-03

Applicant: Genentech, Inc.

Inventor： Germaine FUH ,  Hans-Peter GERBER ,  Wei-Ching LIANG ,  Frederic FELLOUSE ,  Sachdev S. SIDHU ,  Christian WIESMANN

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

公开(公告)号：US20160008427A1

公开(公告)日：2016-01-14

申请号：US14690891

申请日：2015-04-20

Applicant: GENENTECH, INC.

Inventor： Sachdev S. SIDHU ,  Bing LI ,  Menno VAN LOOKEREN CAMPAGNE ,  Christian WIESMANN

IPC: A61K38/17

CPC classification number: A61K38/1774 ,  A61K38/00 ,  C07K14/70503 ,  Y02A50/463

Abstract: The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.

Abstract translation: 本发明涉及亲和力成熟的CRIg变体。 特别地，本发明涉及具有增加的对C3b的结合亲和力并保留在C3上选择性结合C3b的CRIg变体。

公开(公告)号：US20150175689A1

公开(公告)日：2015-06-25

申请号：US14603693

申请日：2015-01-23

Applicant: GENENTECH, INC.

Inventor： Germaine FUH ,  Hans-Peter GERBER ,  Wei-Ching LIANG ,  Frederic FELLOUSE ,  Sachdev S. SIDHU ,  Christian WIESMANN

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/552 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6845

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。