公开(公告)号：US20150056207A1

公开(公告)日：2015-02-26

申请号：US14198359

申请日：2014-03-05

申请人： Genentech, Inc.

发明人： Ellen Filvaroff ,  Mark Merchant ,  Robert L. Yauch

IPC分类号： A61K31/517 ,  A61K45/06 ,  C12N15/113 ,  A61K39/395

CPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C12N15/1135 ,  C12N2310/122 ,  C12N2320/31 ,  A61K2300/00

摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to combination therapies for the treatment of pathological conditions, such as cancer.

公开(公告)号：US20140323706A1

公开(公告)日：2014-10-30

申请号：US13850095

申请日：2013-03-25

申请人： GENENTECH, INC.

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC分类号： C07K14/705

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/54 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N2500/04

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。