公开(公告)号：US20170042967A1

公开(公告)日：2017-02-16

申请号：US15065777

申请日：2016-03-09

Applicant: GENENTECH, INC.

Inventor： Avi Ashkenazi ,  Karim Yussef Helmy ,  Sherman Fong ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth James Katschke, Jr. ,  Menno Van Lookeren ,  William I. Wood

IPC: A61K38/17 ,  C07K14/705

CPC classification number: A61K38/177 ,  A61K38/17 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/77 ,  C07K2319/30 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.

Abstract translation: 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。

公开(公告)号：US20140193332A1

公开(公告)日：2014-07-10

申请号：US14071257

申请日：2013-11-04

Applicant: GENENTECH, INC.

Inventor： Audrey Goddard ,  Austin L. Gurney

IPC: C07K16/28 ,  G01N33/53 ,  C12Q1/68 ,  C07K14/705 ,  A61K51/10

CPC classification number: C07K16/28 ,  A61K47/6843 ,  A61K51/1018 ,  A61K51/1027 ,  C07K14/4713 ,  C07K14/705 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/53 ,  G01N2800/065

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of inflammatory bowel diseases in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于诊断和治疗哺乳动物炎症性肠病的物质组合物，以及使用该物质组合物的方法。

公开(公告)号：US20130331553A1

公开(公告)日：2013-12-12

申请号：US13734261

申请日：2013-01-04

Applicant: Genentech, Inc.

Inventor： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Melanie R. Mark ,  Ruey-Bing Yang

IPC: C07K16/28

CPC classification number: C07K16/28 ,  C07K16/2896

Abstract: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285, PRO286, and PRO358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285, or PRO286, or PRO358 Toll protein.

Abstract translation: 本发明涉及鉴定和分离编码人Toll蛋白PRO285，PRO286和PRO358的新型DNA，以及重组生产这些蛋白质的方法和手段。 本发明还涉及特异性结合PRO285或PRO286或PRO358 Toll蛋白的抗体。

公开(公告)号：US20140323706A1

公开(公告)日：2014-10-30

申请号：US13850095

申请日：2013-03-25

Applicant: GENENTECH, INC.

Inventor： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Daniel Tumas ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC: C07K14/705

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/54 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N2500/04

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。