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    DUAL SPECIFIC ANTIBODIES
    4.
    发明申请
    DUAL SPECIFIC ANTIBODIES 审中-公开
    双特异性抗体

    公开(公告)号：US20160257744A1

    公开(公告)日：2016-09-08

    申请号：US15167030

    申请日：2016-05-27

    Applicant: Genentech, Inc.

    Inventor： Germaine FUH ,  Chingwei V. LEE ,  Patrick KOENIG

    IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

    Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.

    Abstract translation: 本发明提供了双重特异性抗体及其制备和使用方法。 通常，双特异性抗体通过鉴定具有静电或疏水性的轻链可变区VL残基的单特异性抗体并且改变编码抗体VH中一个或多个溶剂可及残基的核酸序列， 与编码抗体VL的核酸序列的改变的组合。 表达改变的VH和VL，并选择双特异性抗体或其抗原结合片段。 还提供了示例性的双特异性抗体以及使用抗体的方法。

    DUAL SPECIFIC ANTIBODIES
    6.
    发明申请
    DUAL SPECIFIC ANTIBODIES 有权

    公开(公告)号：US20250109195A1

    公开(公告)日：2025-04-03

    申请号：US18980433

    申请日：2024-12-13

    Applicant: Genentech, Inc.

    Inventor： Germaine FUH ,  Chingwei V. LEE ,  Patrick KOENIG

    IPC: C07K16/24 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/46

    Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.

    DUAL SPECIFIC ANTIBODIES
    9.
    发明申请
    DUAL SPECIFIC ANTIBODIES 审中-公开

    公开(公告)号：US20200255512A1

    公开(公告)日：2020-08-13

    申请号：US16860891

    申请日：2020-04-28

    Applicant: Genentech, Inc.

    Inventor： Germaine FUH ,  Chingwei V. LEE ,  Patrick KOENIG

    IPC: C07K16/24 ,  C07K16/46 ,  A61K45/06 ,  A61K39/395

    Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.

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