公开(公告)号：US20250042979A1

公开(公告)日：2025-02-06

申请号：US18432414

申请日：2024-02-05

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P25/28 ,  C07K16/00

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20250127891A1

公开(公告)日：2025-04-24

申请号：US18729273

申请日：2023-01-18

Applicant: Chugai Seiyaku Kabushiki Kaisha ,  Hoffmann-La Roche Inc. ,  Genentech, Inc.

Inventor： Takatoshi Ozawa ,  Hiroaki Ida ,  Hajime Ito ,  Shunsuke Yoshida ,  Jillian Smith ,  Sian Lennon-Chrimes ,  Gaelle Klingelschmitt ,  Hans-Christian Von Buedingen ,  Hanna Silber Baumann ,  James Overell ,  Sharmila Rajan

IPC: A61K39/395 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K39/00 ,  A61K45/06

Abstract: All currently available treatment options for autoimmune encephalitis such as anti-NMDAR encephalitis and anti-LGI1 encephalitis carry substantial potential safety risks. Further, no approved therapies exist for anti-NMDAR encephalitis and anti-LGI1 encephalitis. The invention provides a means for a treatment for autoimmune encephalitis (AIE) such as NMDAR encephalitis and anti-LGI1 encephalitis, comprising an IL-6 inhibitor such as anti-IL-6 receptor antibody or antigen binding fragment thereof.

公开(公告)号：US20240076358A1

公开(公告)日：2024-03-07

申请号：US18165142

申请日：2023-02-06

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06 ,  A61P25/28 ,  C07K16/00

CPC classification number: C07K16/18 ,  A61K9/0019 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/28 ,  C07K16/00 ,  A61K2039/505

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20230123110A1

公开(公告)日：2023-04-20

申请号：US17829750

申请日：2022-06-01

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  A61K31/185 ,  A61P25/28 ,  A61K31/4745 ,  C07K16/00 ,  A61K31/13 ,  A61K31/4418 ,  A61K31/405 ,  A61K9/00 ,  A61K31/455 ,  A61K39/395 ,  A61K31/519 ,  A61K45/06

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20210363230A1

公开(公告)日：2021-11-25

申请号：US17139493

申请日：2020-12-31

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  C07K16/00 ,  A61P25/28 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20200377582A1

公开(公告)日：2020-12-03

申请号：US16723550

申请日：2019-12-20

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  C07K16/00 ,  A61P25/28 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US20190016791A1

公开(公告)日：2019-01-17

申请号：US16070150

申请日：2017-01-20

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  A61P25/28 ,  A61K9/00 ,  A61K39/395 ,  A61K45/06 ,  A61K31/13 ,  A61K31/4745 ,  A61K31/405 ,  A61K31/519 ,  A61K31/455 ,  A61K31/185 ,  A61K31/4418

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.