公开(公告)号：US20220122690A1

公开(公告)日：2022-04-21

申请号：US17378651

申请日：2021-07-16

Applicant: GENENTECH, INC.

Inventor： Kai Liu ,  Nicolas Winston Lounsbury ,  William John Thrift ,  Adric Quade Broadwell ,  Lélia Yvonne Delamarre ,  Suchit Sushil Jhunjhunwala

IPC: G16B15/30 ,  G16B40/20 ,  G06N3/04 ,  A61K39/00 ,  G16H20/10

Abstract: Embodiments disclosed herein generally relate to using an attention-based machine learning model to generate an output that includes at least one of an interaction prediction for a target interaction, an interaction affinity prediction, or an immunogenicity prediction relating to a target interaction for a corresponding peptide-immunoprotein complex (IPC) combination. A target interaction may be between a peptide and an immunogenicity complex (IPC) such as, for example, a major histocompatibility complex (MHC), a T cell receptor (TCR), or both. A pharmaceutical composition may be identified, manufactured, and/or used that includes one or more peptides for which one or more target interactions are predicted to be more likely. Methods of treatment may be defined and/or used that include administration of such a pharmaceutical composition.