公开(公告)号：US20160069895A1

公开(公告)日：2016-03-10

申请号：US14850864

申请日：2015-09-10

Applicant: GENENTECH, INC.

Inventor： Lelia DELAMARRE ,  Patrick LUPARDUS ,  Ira MELLMAN ,  Mahesh YADEV ,  Suchit JHUNJHUNWALA ,  Jennie LILL

IPC: G01N33/68 ,  A61K39/00 ,  A61K39/395 ,  C12Q1/68

CPC classification number: G01N33/6848 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/55516 ,  A61K2039/55561 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N33/56977 ,  G01N33/6878 ,  G01N2333/70539 ,  G01N2800/7028

Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

Abstract translation: 本公开提供了通过一系列选择步骤鉴定疾病特异性免疫原性肽的方法。 通过本公开的方法鉴定的免疫原性表位可应用于基于肽的免疫治疗，优选癌症治疗。 此外，本公开的方法可以以高通量方式进行，并且用作个性化疫苗开发和治疗的手段。 还提供了免疫原性肽的组合物以及包含所述组合物的治疗方法。