公开(公告)号：US20160060353A1

公开(公告)日：2016-03-03

申请号：US14489810

申请日：2014-09-18

Applicant: GENENTECH, INC.

Inventor： Henry B. LOWMAN ,  Resi B. GERSTNER ,  Paul J. CARTER

IPC: C07K16/32 ,  A61J1/00

CPC classification number: C07K16/32 ,  A61J1/00 ,  A61J1/18 ,  A61J2205/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains