公开(公告)号：US20160368985A1

公开(公告)日：2016-12-22

申请号：US15184690

申请日：2016-06-16

Applicant: Genentech, Inc.

Inventor： Isidro HOTZEL ,  Teemu T. JUNTTILA ,  Ji LI ,  Justin SCHEER ,  Danielle DICARA ,  Diego ELLERMAN ,  Christoph SPIESS ,  Paul J. CARTER

IPC: C07K16/28 ,  G01N33/574 ,  A61K45/06 ,  A61K47/48 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

Abstract translation: 本发明涉及抗FcRH5抗体，包括抗FcRH5抗体，其包含FcRH5结合结构域和CD3结合结构域（例如，FcRH5T细胞依赖性双特异性（TDB）抗体）及其使用方法。

公开(公告)号：US20140322756A1

公开(公告)日：2014-10-30

申请号：US14142663

申请日：2013-12-27

Applicant: GENENTECH, INC.

Inventor： W. Robert ARATHOON ,  Paul J. CARTER ,  Anne M. MERCHANT ,  Leonard G. PRESTA

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K38/00 ,  C07K1/22 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/732 ,  Y10S435/972

Abstract: The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method provides a multispecific antibody having a common light chain associated with each heteromeric polypeptide having an antibody binding domain. Additionally the method further involves introducing into the multispecific antibody a specific and complementary interaction at the interface of a first polypeptide and the interface of a second polypeptide, so as to promote heteromultimer formation and hinder homomultimer formation; and/or a free thiol-containing residue at the interface of a first polypeptide and a corresponding free thiol-containing residue in the interface of a second polypeptide, such that a non-naturally occurring disulfide bond is formed between the first and second polypeptide. The method allows for the enhanced formation of the desired heteromultimer relative to undesired heteromultimers and homomultimers.

Abstract translation: 本发明涉及制备异源多聚体多肽如双特异性抗体，双特异性免疫粘附素和抗体免疫粘附素嵌合体的方法。 本发明还涉及使用该方法制备的异源多聚体。 通常，该方法提供具有与具有抗体结合结构域的每个异聚多肽相关联的共同轻链的多特异性抗体。 另外，该方法还包括将多特异性抗体引入第一多肽的界面处的第二多肽的界面上的特异性和互补相互作用，以促进异源多聚体形成并阻碍同源多聚体形成; 和/或在第二多肽的界面处的第一多肽和相应的游离含硫醇残基的界面处的游离含硫醇残基，使得在第一和第二多肽之间形成非天然存在的二硫键。 该方法允许相对于不想要的异多元反应物和同源多聚体增强所需异源多聚体的形成。

公开(公告)号：US20210072250A1

公开(公告)日：2021-03-11

申请号：US16951802

申请日：2020-11-18

Applicant: Genentech, Inc.

Inventor： Qianting ZHAI ,  Paul J. CARTER

IPC: G01N33/68 ,  G01N33/53 ,  C07K16/44 ,  C07K16/18 ,  G01N33/52 ,  G01N33/533

Abstract: The invention provides anti-hypusine antibodies and their use in detecting and isolating polypeptides containing hypusine and/or deoxyhypusine, as well as compositions and kits comprising the anti-hypusine antibodies.

公开(公告)号：US20160244525A1

公开(公告)日：2016-08-25

申请号：US14934059

申请日：2015-11-05

Applicant: GENENTECH, INC.

Inventor： Yiyuan YIN ,  Avi ASHKENAZI ,  Paul J. CARTER ,  Mark CHEN ,  Junichiro SONODA

IPC: C07K16/28 ,  C07K16/40 ,  C12P21/02 ,  C07K16/30

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C12P21/02

Abstract: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.

Abstract translation: 本发明提供双重特异性抗FGFR2和FGFR3（FGFR2 / 3）抗体，以及包含使用这些抗体的组合物。

公开(公告)号：US20190315860A1

公开(公告)日：2019-10-17

申请号：US16395009

申请日：2019-04-25

Applicant: Genentech, Inc.

Inventor： Isidro HOTZEL ,  Teemu T. JUNTTILA ,  Ji LI ,  Justin SCHEER ,  Danielle DICARA ,  Diego ELLERMAN ,  Christoph SPIESS ,  Paul J. CARTER

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/30 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US20180328938A1

公开(公告)日：2018-11-15

申请号：US15907152

申请日：2018-02-27

Applicant: Genentech, Inc.

Inventor： Qianting ZHAI ,  Paul J. CARTER

IPC: G01N33/68 ,  C07K16/18 ,  G01N33/533 ,  G01N33/53 ,  G01N33/52

CPC classification number: G01N33/6812 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  G01N33/521 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/6872 ,  G01N2800/50

Abstract: The invention provides anti-hypusine antibodies and their use in detecting and isolating polypeptides containing hypusine and/or deoxyhypusine, as well as compositions and kits comprising the anti-hypusine antibodies.

公开(公告)号：US20160060353A1

公开(公告)日：2016-03-03

申请号：US14489810

申请日：2014-09-18

Applicant: GENENTECH, INC.

Inventor： Henry B. LOWMAN ,  Resi B. GERSTNER ,  Paul J. CARTER

IPC: C07K16/32 ,  A61J1/00

CPC classification number: C07K16/32 ,  A61J1/00 ,  A61J1/18 ,  A61J2205/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains