公开(公告)号：US20170198030A1

公开(公告)日：2017-07-13

申请号：US15239225

申请日：2016-08-17

Applicant: Genentech, Inc.

Inventor： Robert Graham

IPC: C07K16/18 ,  C12Q1/68

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US20170369559A9

公开(公告)日：2017-12-28

申请号：US15239225

申请日：2016-08-17

Applicant: Genentech, Inc.

Inventor： Robert Graham

IPC: C07K16/18 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US20170159114A1

公开(公告)日：2017-06-08

申请号：US15215426

申请日：2016-07-20

Applicant: GENENTECH, INC.

Inventor： Robert Graham ,  Timothy W. Behrens ,  Tsontcho Ianchulev ,  Howard Shapiro

IPC: C12Q1/68 ,  C07K16/22

CPC classification number: C12Q1/6846 ,  C07K16/22 ,  C12Q1/6883 ,  C12Q2531/113 ,  C12Q2531/137 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.