公开(公告)号：US20190001001A1

公开(公告)日：2019-01-03

申请号：US15640880

申请日：2017-07-03

Applicant: General Electric Company ,  University of California San Francisco

Inventor： Paul Francis Fitzgerald ,  Michael Ernest Marino ,  Peter Michael Edic ,  Daniel Eugene Meyer ,  Peter J. Bonitatibus, Jr. ,  Robert Edgar Colborn ,  Benjamin Ming-Yueh Yeh

IPC: A61K49/04

Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.

公开(公告)号：US20200232938A1

公开(公告)日：2020-07-23

申请号：US16745836

申请日：2020-01-17

Applicant: General Electric Company

Inventor： Paul Francis Fitzgerald ,  John Scott Price ,  William Robert Ross ,  Mingye Wu ,  Lin Fu ,  Michelle Brault ,  Bruno Kristiaan Bernard De Man ,  Xin Li

IPC: G01N23/046 ,  G06T7/00 ,  G06T11/00

Abstract: The present disclosure relates to the design of phantoms configurable using one or more inserts and to their use in generating images that may be used to compare image quality between different imaging systems. Such phantoms may have a modular design with inserts that may be exchanged one for another within a phantom body.

公开(公告)号：US10213172B2

公开(公告)日：2019-02-26

申请号：US15044787

申请日：2016-02-16

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Yannan Jin ,  Bruno Kristiaan Bernard De Man ,  Peter Michael Edic ,  Paul Francis Fitzgerald ,  Xue Rui ,  Yangyang Yao ,  Zhye Yin ,  Uwe Wiedmann

IPC: A61B6/00 ,  A61B6/03

Abstract: An imaging method includes executing a low-dose preparatory scan to an object by applying tube voltages and tube currents in an x-ray source, and generating a first image of the object corresponding to the low-dose preparatory scan. The method further includes generating image quality estimates and dose estimates view by view at least based on the first image. The method includes optimizing the tube voltages and the tube currents to generate optimal profiles for the tube voltage and the tube current. At least one of the optimal profiles for the tube voltage and the tube current is generated based on the image quality estimates and the dose estimates. The method includes executing an acquisition scan by applying the tube voltages and the tube currents based on the optimal profiles and generating a second image of the object corresponding to the acquisition scan. An imaging system is also provided.

公开(公告)号：US20190001002A1

公开(公告)日：2019-01-03

申请号：US16026854

申请日：2018-07-03

Applicant: General Electric Company ,  University of California San Francisco

Inventor： Paul Francis Fitzgerald ,  Michael Ernest Marino ,  Peter Michael Edic ,  Daniel Eugene Meyer ,  Peter J. Bonitatibus, JR. ,  Robert Edgar Colborn ,  Benjamin Ming-Yueh Yeh

IPC: A61K49/04

Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.

公开(公告)号：US20160242712A1

公开(公告)日：2016-08-25

申请号：US15044787

申请日：2016-02-16

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Yannan Jin ,  Bruno Kristiaan Bernard De Man ,  Peter Michael Edic ,  Paul Francis Fitzgerald ,  Xue Rui ,  Yangyang Yao ,  Zhye Yin ,  Uwe Wiedmann

IPC: A61B6/00 ,  A61B6/03

CPC classification number: A61B6/405 ,  A61B6/032 ,  A61B6/4233 ,  A61B6/488 ,  A61B6/5205 ,  A61B6/542

Abstract: An imaging method includes executing a low-dose preparatory scan to an object by applying tube voltages and tube currents in an x-ray source, and generating a first image of the object corresponding to the low-dose preparatory scan. The method further includes generating image quality estimates and dose estimates view by view at least based on the first image. The method includes optimizing the tube voltages and the tube currents to generate optimal profiles for the tube voltage and the tube current. At least one of the optimal profiles for the tube voltage and the tube current is generated based on the image quality estimates and the dose estimates. The method includes executing an acquisition scan by applying the tube voltages and the tube currents based on the optimal profiles and generating a second image of the object corresponding to the acquisition scan. An imaging system is also provided.

Abstract translation: 成像方法包括通过在x射线源中施加管电压和管电流来对对象执行低剂量预备扫描，以及生成对应于低剂量预备扫描的对象的第一图像。 该方法还包括至少基于第一图像通过视图生成图像质量估计和剂量估计视图。 该方法包括优化管电压和管电流以产生管电压和管电流的最佳轮廓。 基于图像质量估计和剂量估计，产生管电压和管电流的最佳曲线中的至少一个。 该方法包括通过基于最佳轮廓施加管电压和管电流来执行采集扫描，并且生成对应于采集扫描的对象的第二图像。 还提供了一种成像系统。