公开(公告)号：US20180057569A1

公开(公告)日：2018-03-01

申请号：US15794541

申请日：2017-10-26

Applicant: GENEURO SA

Inventor： Corinne BERNARD ,  Alois Bernhardt LANG ,  Herve PERRON ,  Jean-Baptiste BERTRAND

IPC: C07K16/10 ,  A61K39/00

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or any sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1 (SEQ ID No.1), from 0 to 2 in CDR2 (SEQ ID No.2), from 0 to 2 in CDR3 (SEQ ID No.3), from 0 to 1 in CDR4 (SEQ ID No.4), from 0 to 4 in CDR5 (SEQ ID No.5), from 0 to 2 in CDR6 (SEQ ID No.6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

公开(公告)号：US20170107274A1

公开(公告)日：2017-04-20

申请号：US15367864

申请日：2016-12-02

Applicant: GENEURO SA

Inventor： Corinne BERNARD ,  Alois Bernhardt LANG ,  Herve PERRON ,  Jean-Baptiste BERTRAND

IPC: C07K16/10

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or any sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1 (SEQ ID No.1), from 0 to 2 in CDR2 (SEQ ID No.2), from 0 to 2 in CDR3 (SEQ ID No.3), from 0 to 1 in CDR4 (SEQ ID No.4), from 0 to 4 in CDR5 (SEQ ID No.5), from 0 to 2 in CDR6 (SEQ ID No.6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

公开(公告)号：US20140220026A1

公开(公告)日：2014-08-07

申请号：US14221963

申请日：2014-03-21

Applicant: GENEURO SA

Inventor： Corinne BERNARD ,  Alois Bernhardt LANG ,  Herve PERRON ,  Jean-Baptiste BERTRAND

IPC: C07K16/10

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or any sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1 (SEQ ID No.1), from 0 to 2 in CDR2 (SEQ ID No.2), from 0 to 2 in CDR3 (SEQ ID No.3), from 0 to 1 in CDR4 (SEQ ID No.4), from 0 to 4 in CDR5 (SEQ ID No.5), from 0 to 2 in CDR6 (SEQ ID No.6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

Abstract translation: 配体包括SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4，SEQ ID No.5和SEQ ID No.6所示的每个互补决定区（CDR） 或在CDR1（SEQ ID No.1）中为0〜3，CDR2（SEQ ID No.2）为0〜2，0〜2的任意序列，在所述序列内具有任意数量的取代氨基酸的序列， 在CDR3（SEQ ID No.3）中，在CDR4（SEQ ID No.4）中为0至1，CDR5（SEQ ID No.5）为0至4，CDR6为0至2（SEQ ID No.6 ）或在所述序列SEQ ID No.1至SEQ ID No.6内具有等同化学功能和性质的其它氨基酸取代的氨基酸。