公开(公告)号：US11795214B2

公开(公告)日：2023-10-24

申请号：US16399424

申请日：2019-04-30

Applicant: GENMAB A/S

Inventor： Paul Parren ,  Patrick Van Berkel ,  Ewald Van Den Bremer

IPC: C07K16/18 ,  C07K16/00 ,  G01N33/50 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K16/00 ,  G01N33/5014 ,  G01N33/6854 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/734

Abstract: Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.