公开(公告)号：US20210230301A1

公开(公告)日：2021-07-29

申请号：US17012102

申请日：2020-09-04

Applicant: GENMAB B.V.

Inventor： Rob N. DE JONG ,  Frank BEURSKENS ,  Paul PARREN ,  Aran Frank LABRIJN ,  Janine SCHUURMAN ,  Arjen VLUG ,  Sandra VERPLOEGEN

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/00 ,  C07K16/32 ,  C07K16/12

Abstract: The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.