公开(公告)号：US12275797B2

公开(公告)日：2025-04-15

申请号：US17253276

申请日：2019-06-24

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Ronald Taylor ,  Margaret Lindorfer ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis ,  Paul Parren ,  Esther Breij

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28

Abstract: The present invention relates to anti-CD37antibodies having an Fc-Fc interaction enhancing substitution in the Fc-region of a human IgG, for use as a medicament in combination with anti-CD20 antibodies having an Fc-Fc interaction enhancing substitution in the Fc-region of a human IgG. The invention also relates to a novel composition of anti-CD37 antibodies having an Fc-Fc 5 interaction enhancing substitution and anti-CD20 antibodies having an Fc-Fc interaction enhancing substitution. In particular, the invention relates to compositions wherein the anti-CD37 antibody binds human CD37 and the anti-CD20 antibody binds human CD20. The invention also relates to compositions where the composition is a pharmaceutical composition and the use of such compositions in treatment of cancer and other diseases.

公开(公告)号：US11512137B2

公开(公告)日：2022-11-29

申请号：US16872140

申请日：2020-05-11

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

公开(公告)号：US11034772B2

公开(公告)日：2021-06-15

申请号：US17066190

申请日：2020-10-08

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.