公开(公告)号：US11512137B2

公开(公告)日：2022-11-29

申请号：US16872140

申请日：2020-05-11

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

公开(公告)号：US11034772B2

公开(公告)日：2021-06-15

申请号：US17066190

申请日：2020-10-08

Applicant: GENMAB HOLDING B.V.

Inventor： Simone Oostindie ,  Frank Beurskens ,  Esther Breij ,  Edward Van Den Brink ,  Andreas Hollenstein ,  Marije Overdijk ,  Margaret Lindorfer ,  Ronald Taylor ,  Paul Parren ,  Hilma Van Der Horst ,  Martine E. D. Chamuleau ,  Tuna Mutis

IPC: C07K16/28 ,  A61P35/00 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.