公开(公告)号：US20240350413A1

公开(公告)日：2024-10-24

申请号：US18686065

申请日：2022-08-24

申请人： GENNOVA BIOPHARMACEUTICALS LTD.

发明人： Swarnendu KAVIRAJ ,  Sanjay SINGH ,  Sunil RAUT ,  Pavan KARDILE ,  Ajay SINGH

IPC分类号： A61K9/19 ,  A61K9/107 ,  A61K9/14 ,  A61K39/00 ,  A61K39/215 ,  A61P31/14

CPC分类号： A61K9/19 ,  A61K9/1075 ,  A61K9/145 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/51 ,  A61K2039/552 ,  A61K2039/55555 ,  C12N2770/20034

摘要： Lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. The present invention relates to lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. It particularly provides a method for lyophilisation of liquid 5 formulations of mRNA adsorbed onto lipid nano-emulsion particles under the conditions that maintain the integrity and pharmaceutical properties of resultant lyophilised formulations for the extended periods at storage temperature of about 5° C.