公开(公告)号：US20150302143A1

公开(公告)日：2015-10-22

申请号：US14440582

申请日：2013-11-04

申请人： GENOMIC HEALTH, INC.

发明人： Yan Ma ,  Kunbin Qu ,  Mei-Lan Liu ,  Ranjana Ambannavar ,  James Stephans ,  John Pan

IPC分类号： G06F19/18 ,  G06F19/22 ,  G06F19/00 ,  C12Q1/68

CPC分类号： G06F19/18 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/22 ,  G16H50/20

摘要： The present invention relates to gene fusions and alternative spliced junctions associated with breast cancer. The present invention also relates to novel methods of identifying gene fusions and alternative spliced junctions in RNA sequencing data. The present invention further relates to predicting prognosis of a breast cancer patient based on the number of gene fusion events.

摘要翻译： 本发明涉及与乳腺癌相关的基因融合体和选择性剪接点。 本发明还涉及鉴定RNA测序数据中的基因融合和可变剪接的新方法。 本发明还涉及基于基因融合事件的数量预测乳腺癌患者的预后。

公开(公告)号：US10169530B2

公开(公告)日：2019-01-01

申请号：US14440582

申请日：2013-11-04

申请人： GENOMIC HEALTH, INC.

发明人： Yan Ma ,  Kunbin Qu ,  Mei-Lan Liu ,  Ranjana Ambannavar ,  James Stephans

IPC分类号： G06F19/18 ,  C12Q1/6886 ,  G06F19/22 ,  G16H50/20

摘要： The present invention relates to gene fusions and alternative spliced junctions associated with breast cancer. The present invention also relates to novel methods of identifying gene fusions and alternative spliced junctions in RNA sequencing data. The present invention further relates to predicting prognosis of a breast cancer patient based on the number of gene fusion events.