公开(公告)号：US20170322199A1

公开(公告)日：2017-11-09

申请号：US15529814

申请日：2015-11-23

Applicant: GENTIUM S.R.L.

Inventor： Terenzio IGNONI ,  Vijay KUMAR ,  Claudio VERGA

IPC: G01N33/50

CPC classification number: G01N33/5014 ,  G01N33/5064

Abstract: The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.

公开(公告)号：US20230194502A1

公开(公告)日：2023-06-22

申请号：US18170644

申请日：2023-02-17

Applicant: GENTIUM S.R.L.

Inventor： Terenzio IGNONI ,  Vijay KUMAR ,  Claudio VERGA

IPC: G01N33/50

CPC classification number: G01N33/5014 ,  G01N33/5064

Abstract: The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.

公开(公告)号：US20200057051A1

公开(公告)日：2020-02-20

申请号：US16551505

申请日：2019-08-26

Applicant: GENTIUM S.R.L.

Inventor： Terenzio IGNONI ,  Vijay KUMAR ,  Claudio VERGA

IPC: G01N33/50

Abstract: The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.