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公开(公告)号：US20230203140A9
公开(公告)日：2023-06-29
申请号：US17282592
申请日：2019-10-02
发明人： Thomas BAYER , Preeti BAKRANIA , Sarah DAVIES , Alex BROWN , Chido MPAMHANGA , David MATTHEWS , Mark CARR , Gareth HALL
CPC分类号： C07K16/18 , A61P25/28 , C07K2317/24 , C07K2317/567 , A61K2039/505
摘要： The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).
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公开(公告)号：US20210347867A1
公开(公告)日：2021-11-11
申请号：US17282592
申请日：2019-10-02
发明人： Thomas BAYER , Preeti BAKRANIA , Sarah DAVIES , Alex BROWN , Chido MPAMHANGA , David MATTHEWS , Mark CARR , Gareth HALL
摘要： The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).
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公开(公告)号：US20230151069A1
公开(公告)日：2023-05-18
申请号：US17905894
申请日：2021-03-10
发明人： Preeti BAKRANIA , David MATTHEWS , Elizabeth LOVE , Chido MPAMHANGA , Thomas BAYER , Mark CARR , Gareth HALL , Richard COWAN
CPC分类号： C07K14/4711 , A61K39/0007 , C07K16/18 , A61P25/28
摘要： The present invention relates to cyclized peptides based on amino acids 1-14 of amyloid-beta. The cyclic peptides are useful for inducing an immune response and as vaccines for the treatment of neurodegenerative diseases such as Alzheimer's disease.
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