公开(公告)号：US12128076B2

公开(公告)日：2024-10-29

申请号：US16959016

申请日：2019-01-14

申请人： GI INNOVATION, INC.

发明人： Myoung Ho Jang ,  Young Chul Sung ,  Zungyoon Yang

IPC分类号： A61K35/745 ,  A61K9/00 ,  A61K9/14 ,  A61K9/19 ,  A61K35/744 ,  A61K35/747 ,  A61K38/17 ,  A61K39/395 ,  A61P37/08 ,  C07K14/735 ,  C07K16/42

CPC分类号： A61K35/745 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/14 ,  A61K9/19 ,  A61K35/744 ,  A61K35/747 ,  A61K38/1774 ,  A61K39/39566 ,  A61P37/08 ,  C07K14/70535 ,  C07K16/4291 ,  C07K2317/52 ,  C07K2317/60 ,  C07K2317/92 ,  C07K2319/30

摘要： A composition containing, as active ingredients, probiotics and a polypeptide with a binding ability to IgE is disclosed. In particular, a synergistic effect of remarkably decreasing food allergy was identified at the time of combined administration of probiotics and a recombinant protein containing an extracellular domain of an alpha subunit of an IgE Fc receptor. Therefore, it is expected that the composition is highly industrially applicable due to being able to exhibit a remarkable therapeutic effect on an IgE-mediated allergic disease as compared with conventional pharmaceutical compositions.