公开(公告)号：US3856828A

公开(公告)日：1974-12-24

申请号：US37947173

申请日：1973-07-16

申请人： GLAXO LAB LTD

发明人： PHILLIPPS G ,  WOOLLETT E ,  MAY P ,  MCDONALD B

IPC分类号： H05K13/02 ,  A61K20060101 ,  A61K31/56 ,  A61K31/565 ,  A61P29/00 ,  C07C20060101 ,  C07D20060101 ,  C07J20060101 ,  C07J1/00 ,  C07J3/00 ,  C07C169/24

CPC分类号： C07J75/00

摘要： The Specification describes compounds of the general formula WHEREIN X represents a hydrogen, chlorine or fluorine atom; R1 represents a Beta -hydroxy group, an oxo group or (when X is a chlorine atom) a Beta -chlorine atom; R2 represents a hydrogen atom, a methylene group or an Alpha or Beta -methyl group; R3 represents a hydrogen atom or C1-4alkyl or phenyl group; R4 represents a methyl group substituted by at least one halogen atom; an ethyl group substituted by at least one fluorine and/or iodine atom; or a propyl group substituted by at least one halogen atom; and represents a single or double bond. The Specification also describes processes for the preparation of compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I have good anti-inflammatory activity, particularly on topical application.

摘要翻译： 该说明书描述了通式的化合物，其中X表示氢，氯或氟原子; R1表示β-羟基，氧代基或（当X为氯原子时）β-氯原子; R2表示氢原子，亚甲基或α-或β-甲基; R3表示氢原子或C1-4烷基或苯基; R4表示被至少一个卤素原子取代的甲基; 被至少一个氟和/或碘原子取代的乙基; 或被至少一个卤素原子取代的丙基; 并且表示单键或双键。 本说明书还描述了制备式I化合物的方法以及含有这些化合物的药物组合物。 式I的化合物具有良好的抗炎活性，特别是局部应用。