公开(公告)号：US20180002679A1

公开(公告)日：2018-01-04

申请号：US15540690

申请日：2015-12-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Jurgen HAAS ,  Julian IHSSEN ,  Michael Thomas KOWARIK ,  Torsten Franz SCHWEDE ,  Linda Christiane THÖNY-MEYER

IPC: C12N9/10 ,  C12P21/00

CPC classification number: C12N9/1081 ,  C12P21/005

Abstract: Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.